| Texto completo | |
| Autor(es): Mostrar menos - |
da Silva Moreira, Milena
;
Schmitz, Giovanna
;
de Sa Alves, Mariana
;
Mendes, Maria Anita
;
Alves, Monica Ghislaine Oliveira
;
Alves, Levy Anderson Cesar
;
Dias, Meriellen
;
Bandeira, Celso Muller
;
Nepomuceno, Gabrielle Luana Jimenez Teodoro
;
da Silva Martinho, Herculano
;
Almeida, Janete Dias
Número total de Autores: 11
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| Tipo de documento: | Artigo Científico |
| Fonte: | RAPID COMMUNICATIONS IN MASS SPECTROMETRY; v. 39, n. 15, p. 6-pg., 2025-05-05. |
| Resumo | |
RationaleOral squamous cell carcinoma (OSCC) is a multifactorial disease, and emerging evidence links the oral microbiome to its development. Rapid, noninvasive identification of salivary microorganisms may offer novel diagnostic and prognostic insights into oral cancer.MethodsSalivary microbiota from OSCC patients and healthy individuals were analyzed using MALDI Biotyper. Saliva samples were cultured, and microbial identification was performed based on protein spectral profiles using an UltrafleXtreme MALDI-TOF mass spectrometer.ResultsThirteen OSCC patients (mean age 55 +/- 11 years; 69% male) and nineteen healthy controls (mean age 55 +/- 10 years; 79% male) were analyzed. Distinct microbial profiles were observed in OSCC patients, including pathogenic species previously associated with carcinogenesis, suggesting potential biomarkers for oral cancer.ConclusionsThe MALDI Biotyper is an effective, noninvasive tool for identifying salivary microbiota. Its application may support early diagnosis and prognosis of OSCC, reinforcing the significance of the oral microbiome in cancer etiology. (AU) | |
| Processo FAPESP: | 16/08633-0 - Tabagismo: dos aspectos moleculares a abordagem do fumante |
| Beneficiário: | Janete Dias Almeida |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |