Autor(es)

Silvestrini, Ana Vitoria Pupo ; da Silva, Ualisson Jose ; Morais, Milena Finazzi ; Depieri, Livia Vieira ; Bentley, Maria Vitoria Lopes Badra

• Tipo de documento: Artigo Científico
• Fonte: BIOMATERIALS ADVANCES; v. 180, p. 28-pg., 2026-03-01.

Resumo

Psoriasis is a chronic, inflammatory, immune-mediated, papulosquamous skin disease with diverse clinical phenotypes. It is frequently associated with cardiometabolic and rheumatologic comorbidities, as well as significant physical and psychological impact, accounting for the fourth largest global burden of disability. Conventional topical and systemic drug therapies constitute the basis of therapeutic protocols; however, their efficacy in alleviating the symptoms, decrease recurrence or resolving inflammation is limited by predominantly single-target mechanisms and pharmacokinetic challenges imposed by extra- and intracellular barriers. In this review, we discuss recent breakthroughs in understanding psoriasis's pathological targets and immunopathogenic mechanisms. Simultaneously, several materials with multifunctional properties have emerged, constituting innovative drug delivery systems, such as nanoparticles and microneedles, specifically designed to improve topical drug delivery, allow precise targeting within the lesion and combination therapies. We highlight the importance of the design and composition of these formulations to improve therapeutic efficacy and their evolution in the administration of various agents, from conventional drugs and natural compounds to therapeutic nucleic acids. To place these advances in a broader context, we integrate recent insights into immunopathogenesis and clinical heterogeneity with material-driven design, demonstrating how nanosystems and microneedles can complement conventional therapies and support the application of emerging multi-targeted approaches. The innovations discussed here open new avenues for optimizing treatment satisfaction and highlight the potential of nanotechnology-driven strategies to revolutionize psoriasis treatment. However, challenges remain in translating these technologies into clinical practice. (AU)

• Processo FAPESP: 14/50928-2 - Inct 2014 - nanotecnologia farmaceutica:uma abordagem transdisciplinar.
• Beneficiário: Maria Vitória Lopes Badra Bentley
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 24/18425-2 - Sistemas nanoestruturados para liberação de fármacos e genes: obtenção por microfluídica e avaliação por microscopia de força atômica e plataforma organ-on-a-chip
• Beneficiário: Lívia Vieira Depieri
• Modalidade de apoio: Bolsas no Brasil - Programa Capacitação - Treinamento Técnico
• Processo FAPESP: 24/05678-0 - Carreador lipídico nanoestruturado para co-entrega de siRNA e berberina na terapia tópica de feridas cutâneas crônicas: desenvolvimento, caracterização físico-química e eficácia in vitro
• Beneficiário: Milena Finazzi Morais
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 22/01969-4 - Nanopartículas líquido-cristalinas multifuncionais para co-liberação de siRNAs e piperina no tratamento tópico do vitiligo: desenvolvimento, caracterização e estudos in vitro
• Beneficiário: Ana Vitória Pupo Silvestrini
• Modalidade de apoio: Bolsas no Brasil - Doutorado