Increased mucin 1 expression in recurrence and malignant transformation of salivary gland pleomorphic adenoma

Autor(es)

Soares, Andresa Borges ^[1] ; Dias Demasi, Ana Paula ^[1] ; Altemani, Albina ^[2] ; de Araujo, Vera Cavalcanti ^[1]

Afiliação do(s) autor(es)

^[1] Sao Leopoldo Mandic Inst & Res Ctr, Dept Oral Pathol, BR-13045755 Campinas, SP - Brazil

^[2] State Univ Campinas UNICAMP, Sch Med, Dept Pathol, Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Histopathology; v. 58, n. 3, p. 377-382, FEB 2011.
• Citações Web of Science: 12

Resumo

Aims: Pleomorphic adenoma (PA) is the most common salivary gland tumour with a tendency to recur (RPA) and a risk of malignant transformation. Mucin 1 (MUC-1) plays a role in the progression of many tumours and may be a marker to predict RPA. The aim of this study was to evaluate MUC-1 expression in different phases of the adenoma to carcinoma sequence. Methods and results: Twenty-one cases of PA, 18 cases of RPA, three cases of RPA with focal transformation (TRPA) and 11 cases of carcinoma ex-pleomorphic adenoma (CXPA) were analysed immunohistochemically for MUC1 expression using an antibody to MUC1/DF3. MUC1 reactivity in RPA was stronger than that observed in PA and, in all the different carcinoma groups, MUC-1 expression was significantly higher in carcinoma than in RPA and PA. Conclusion: This study has confirmed that MUC-1 is related to the recurrence of PA and that this molecule is associated with malignant transformation of PA with carcinoma cells overexpressing MUC-1. (AU)

• Processo FAPESP: 07/55206-1 - Adenoma pleomórfico recidivado: fatores de risco para recidiva e transformação maligna
• Beneficiário: Andresa Borges Soares
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 08/50167-0 - Adenoma pleomórfico recidivado: fatores de risco para recidiva e transformação maligna
• Beneficiário: Vera Cavalcanti de Araujo
• Modalidade de apoio: Auxílio à Pesquisa - Regular