Peripheral Oxidative Stress Biomarkers in Mild Cognitive Impairment and Alzheimer's Disease

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Torres, Larissa Lobo ; Quaglio, Nathalia Barbosa ; de Souza, Gisele Tavares ; Garcia, Raphael Tamborelli ; Munhoz Dati, Livia Mendonca ; Moreira, Wallace Luiz ; de Melo Loureiro, Ana Paula ; de Souza-Talarico, Juliana Nery ^{[1, 2]} ; Smid, Jerusa ^[1] ; Porto, Claudia Selito ^[1] ; de Campos Bottino, Cassio Machado ^[3] ; Nitrini, Ricardo ^[1] ; de Moraes Barros, Silvia Berlanga ; Camarini, Rosana ^[4] ; Marcourakis, Tania ^[5]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Behav & Cognit Neurol Unit, Dept Neurol, BR-05508900 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Dept Med Surg Nursing, Sch Nursing, BR-05508900 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Dept Psychiat, Sch Med, BR-05508900 Sao Paulo - Brazil

^[4] Univ Sao Paulo, Dept Pharmacol, Inst Biomed Sci, BR-05508900 Sao Paulo - Brazil

^[5] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Clin Chem & Toxicol, Sch Pharmaceut Sci, BR-05508900 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF ALZHEIMER'S DISEASE; v. 26, n. 1, p. 59-68, 2011.
• Citações Web of Science: 113

Resumo

Oxidative stress has been associated with normal aging and Alzheimer's disease (AD). However, little is known about oxidative stress in mild cognitive impairment (MCI) patients who present a high risk for developing AD. The aim of this study was to investigate plasma production of the lipid peroxidation marker, malonaldehyde (MDA) and to determine, in erythrocytes, the enzymatic antioxidant activity of catalase, glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione S-transferase (GST) in 33 individuals with MCI, 29 with mild probable AD and 26 healthy aged subjects. GR/GPx activity ratio was calculated to better assess antioxidant defenses. The relationship between oxidative stress and cognitive performance was also evaluated by the Mini Mental State Examination (MMSE). AD patients showed higher MDA levels than both MCI and healthy elderly subjects. MCI subjects also exhibited higher MDA levels compared to controls. Catalase and GPx activity were similar in MCI and healthy individuals but higher in AD. GR activity was lower in MCI and AD patients than in healthy aged subjects. Additionally, GR/GPx ratio was higher in healthy aged subjects, intermediate in MCI and lower in AD patients. No differences in GST activity were detected among the groups. MMSE was negatively associated with MDA levels (r = -0.31, p = 0.028) and positively correlated with GR/GPx ratio in AD patients (r = 0.68, p < 0.001). MDA levels were also negatively correlated to GR/GPx ratio (r = -0.31, p = 0.029) in the AD group. These results suggest that high lipid peroxidation and decreased antioxidant defenses may be present early in cognitive disorders. (AU)

• Processo FAPESP: 04/10205-0 - Envelhecimento e doença de Alzheimer: processos contínuos? efeito dos anticolinesterásicos e antioxidantes
• Beneficiário: Tania Marcourakis
• Modalidade de apoio: Auxílio à Pesquisa - Regular