Analytical Potentialities of Carbon Nanotube/Silicone Rubber Composite Electrodes: Determination of Propranolol

Autor(es)

dos Santos, Sidney Xavier ^{[1, 2]} ; Cavalheiro, Eder T. G. ^[1] ; Brett, Christopher M. A. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Quim & Fis Mol, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil

^[2] Univ Coimbra, Dept Quim, Fac Ciencias & Tecnol, P-3004535 Coimbra - Portugal

• Tipo de documento: Artigo Científico
• Fonte: Electroanalysis; v. 22, n. 23, p. 2776-2783, DEC 2010.
• Citações Web of Science: 12

Resumo

A new composite electrode based on multiwall carbon nanotubes (MWCNT) and silicone-rubber (SR) was developed and applied to the determination of propranolol in pharmaceutical formulations. The effect of using MWCNT/graphite mixtures in different proportions was also investigated. Cyclic voltammetry and electrochemical impedance spectroscopy were used for electrochemical characterization of different electrode compositions. Propranolol was determined using MWCNT/SR 70% (m/m) electrodes with linear dynamic ranges up to 7.0 mu molL(-1) by differential pulse and up to 5.4 mu molL(-1) by square wave voltammetry, with LODs of 0.12 and 0.078 mu molL(-1), respectively. Analysis of commercial samples agreed with that obtained by the official spectrophotometric method. The electrode is mechanically robust and presented reproducible results and a long useful life. (AU)

• Processo FAPESP: 08/03537-7 - Desenvolvimento e aplicação de eletrodos compósitos à base de grafite-poliuretana e grafite-borracha de silicone-III: modificação com nanotubos de carbono e polímeros molecularmente impressos
• Beneficiário: Éder Tadeu Gomes Cavalheiro
• Modalidade de apoio: Auxílio à Pesquisa - Regular