Modeling for Taxol (R) Separation in a Simulated Moving Bed

Autor(es)

Cremasco, Marco Aurelio ^[1] ; Starquit, Axel Nicolas ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Fac Engn Quim, BR-13083970 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Archives of Biology and Technology; v. 53, n. 6, p. 1433-1441, NOV-DEC 2010.
• Citações Web of Science: 1

Resumo

This work presents an alternative numerical resolution strategy for a model to describe the dynamic of linear adsorption processes involving multicomponent mixture of taxanes with Taxol (R) (paclitaxel), a powerful anti-cancer agent, and non-identified impurities, in a Simulated Moving Bed (SMB) system. To solve the model, a hybrid method were used. The liquid concentration inside the particles was found analytically and was related with the liquid bed concentration using Duhamel's theorem. The results from simulation were compared with experimental ones from the literature, showing a good agreement, which demonstrated the applicability of the model and of the hybrid resolution proposed. (AU)

• Processo FAPESP: 01/08101-3 - Modelagem e simulação de sistema cromatográfico em leito móvel simulado visando à separação e purificação de fármacos e correlatos
• Beneficiário: Marco Aurélio Cremasco
• Modalidade de apoio: Auxílio à Pesquisa - Regular