IMMUNOHISTOCHEMICAL DISTRIBUTION OF AMPA-TYPE LABEL IN THE PIGEON (C. LIVIA) HIPPOCAMPUS

Autor(es)

Rosinha, M. U. ^[1] ; Ferrari, E. A. M. ^[2] ; Toledo, C. A. B. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Cidade Sao Paulo, Lab Neurociencia, BR-03071000 Sao Paulo - Brazil

^[2] Univ Estadual Campinas, Dept Fisiol Biofis, BR-13083970 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Neuroscience; v. 159, n. 2, p. 438-450, MAR 17 2009.
• Citações Web of Science: 6

Resumo

The avian hippocampal formation (HF) is reported to have a role equivalent to that of the mammalian hippocampus, which may involve the glutamatergic system as well. In the present paper we offer evidence of the occurrence and distribution of the subunits composing AMPA-type glutamate receptors on neurons in the hippocampus region of the pigeon brain. The experiment analyzed the immunolabeling of glutamate receptor (GluR)(1), GluR(4), and GluR(2/3) receptor subunits in adult pigeons and found consistent evidence that neurons located in the five main areas of the avian HF have these AMPA-type subunits, but their incidence varies according to position and neuro-type. About 20%-35% of the irregular and 35%-70% of the triangular neurons on the lateral and medial ``V{''} arms contain GluR(1) and GluR(2/3), while GluR(4) Was found only at rounded neurons. The majority of the triangular neurons (over 90%) and about half of the irregular neurons in the medial area contain GluR, and GluR(2/3), whereas the rounded neurons contain primarily GluR(4) (95%). Labeling revealed GluR(1) (40%-60%) and GluR(2/3) (30%) in the dorsomedial and lateral areas but only in irregular neurons, while 60%-80% of the rounded neurons synthesize GluR(4). While triangular and irregular neurons appear to match the description of projecting neurons, rounded ones seem to participate in local circuits. A discussion of the functional significance of the avian HF concentrates on a postulation of the ``V{''} arms as equivalent to the dentate gyrus and the dorsomedial area being similar to the Ammon's horn. (C) 2009 IBRO. Published by Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 04/11039-6 - Distribuição dos receptores ionotrópicos de glutamato no sistema nervoso de vertebrados
• Beneficiário: Sandra Regina Mota Ortiz
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 00/04536-2 - Organização funcional dos sistemas glutamatérgico e serotonérgico nas áreas visuais subcorticais envolvidas nos reflexos oculares
• Beneficiário: Sandra Regina Mota Ortiz
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 08/51110-2 - Aspectos funcionais dos receptores ionotropicos de glutamato no sistema nervoso de vertebrados.
• Beneficiário: Sandra Regina Mota Ortiz
• Modalidade de apoio: Auxílio à Pesquisa - Regular