| Texto completo | |
| Autor(es): |
Stolic, Ivana
[1]
;
Miskovic, Katarina
[2]
;
Magdaleno, Anahi
[3]
;
Silber, Ariel Mariano
[3]
;
Piantanida, Ivo
[4]
;
Bajic, Miroslav
[1]
;
Glavas-Obrovac, Ljubica
[2]
Número total de Autores: 7
|
| Afiliação do(s) autor(es): | [1] Univ Zagreb, Dept Chem & Biochem, Fac Vet Med, Zagreb 10000 - Croatia
[2] JJ Strossmayer Univ Osijek, Dept Med Chem & Biochem, Sch Med, Osijek 31000 - Croatia
[3] Univ Sao Paulo, Dept Parasitol, Inst Biomed Sci, Sao Paulo - Brazil
[4] Rudjer Boskovic Inst, Div Organ Chem & Biochem, Zagreb - Croatia
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Bioorganic & Medicinal Chemistry; v. 17, n. 6, p. 2544-2554, MAR 15 2009. |
| Citações Web of Science: | 25 |
| Resumo | |
Novel bisbenzimidazoles (4-6), characterized by 3,4-ethylenedioxy-extension of thiophene core, revealed pronounced affinity and strong thermal stabilization effect toward ds-DNA. They interact within ds-DNA grooves as dimmers or even oligomers and agglomerate along ds-RNA. Compounds 4-6 have shown moderate to strong antiproliferative effect toward panel of eight carcinoma cell lines. Compound 5 displayed the best inhibitory potential and in equitoxic concentration (IC(50) = 1 x 10 (6) M) induced accumulation of cells in G2/M phase after 48 h of incubation. Fluorescence microscopy showed that 5 entered into live HeLa cells within 30 min, but did not accumulate in nuclei even after 2.5 h. Compound 5 inhibited the growth of Trypanosome cruzi epimastigotes (IC(50) = 4.3 x 10 (6) M). (C) 2009 Elsevier Ltd. All rights reserved. (AU) | |
| Processo FAPESP: | 03/13257-8 - Clonagem e caracterização de transportadores de aminoácidos em Trypanosoma cruzi: uma abordagem pós-genômica |
| Beneficiário: | Ariel Mariano Silber |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |