Low-level laser therapy improves bone repair in rats treated with anti-inflammatory drugs

Autor(es)

Ribeiro, D. A. ^[1] ; Matsumoto, M. A. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Biosci, BR-11060001 Santos, SP - Brazil

^[2] Univ Sagrado Coracao, Sch Dent, Dept Oral Maxillofacial Surg, USC, Bauru, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Oral Rehabilitation; v. 35, n. 12, p. 925-933, DEC 2008.
• Citações Web of Science: 27

Resumo

Nowadays, selective cyclooxygenase-2 non-steroidal anti-inflammatory drugs have been largely used in surgical practice for reducing oedema and pain. However, the association between these drugs and laser therapy is not known up to now. Herein, the aim of this study was to evaluate the action of anti-COX-2 selective drug (celecoxib) on bone repair associated with laser therapy. A total of 64 rats underwent surgical bone defects in their tibias, being randomly distributed into four groups: Group 1) negative control; Group 2) animals treated with celecoxib; Group 3) animals treated with low-level power laser and Group 4) animals treated with celecoxib and low-level power laser. The animals were killed after 48 h, 7, 14 and 21 days. The tibias were removed for morphological, morphometric and immunohistochemistry analysis for COX-2. Statistical significant differences (P < 0.05) were observed in the quality of bone repair and quantity of formed bone between groups at 14 days after surgery for Groups 3 and 4. COX-2 immunoreactivity was more intense in bone cells for intermediate periods evaluated in the laser-exposed groups. Taken together, such results suggest that low-level laser therapy is able to improve bone repair in the tibia of rats as a result of an up-regulation for cyclooxygenase-2 expression in bone cells. (AU)

• Processo FAPESP: 04/09748-9 - Influencia de drogas nao-esteroidais nao especificas e especificas para cox-2 no processo de reparo osseo em tibias de ratos.
• Beneficiário: Mariza Akemi Matsumoto
• Modalidade de apoio: Auxílio à Pesquisa - Regular