A pilot case-control association study of cytokine polymorphisms in Brazilian women presenting with HPV-related cervical lesions

Autor(es)

Fernandes, Ana Paula M. ^[1] ; Goncalves, Maria Alice G. ^[2] ; Simoes, Renata T. ^[2] ; Mendes-Junior, Celso T. ^[2] ; Duarte, Geraldo ^[3] ; Donadi, Eduardo A. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Nursing Sch Ribeirao Preto, Dept Gen & Specialized Nursing, BR-14049900 Ribeirao Preto - Brazil

^[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Med, Div Clin Immunol, BR-14049900 Ribeirao Preto - Brazil

^[3] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Obstet & Gynaecol, BR-14049900 Ribeirao Preto - Brazil

• Tipo de documento: Artigo Científico
• Fonte: EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY; v. 140, n. 2, p. 241-244, OCT 2008.
• Citações Web of Science: 14

Resumo

Objective and study design: A case-control study was conducted on 42 Brazilian women presenting with human papilloma virus (HPV) infection and cervical lesion and 87 HPV-negative women to evaluate single nucleotide polymorphisms observed in TNF-alpha, TGF-beta, IL-10, IL-6, and IFN-gamma genes. Results and conclusion: No significant association was observed on the cytokine polymorphisms analyzed in this series. Larger studies using cytokine polymorphisms may be useful for providing further information regarding their influence or not in HPV-related cervical lesions. (C) 2008 Elsevier Ireland Ltd. All rights reserved. (AU)

• Processo FAPESP: 97/04490-8 - Dinâmica da interação entre HIV-HPV na população feminina das cidades de Santos e Marília, São Paulo, Brasil
• Beneficiário: Eduardo Massad
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 01/02908-2 - Influência da imunodeficiência como fator de risco na patogênese das Neoplasias Intraepiteliais Cervicais (NIC)
• Beneficiário: Maria Alice Guimarães Gonçalves
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado