The Use of Ultrasonography to Study Teratogenicity in Ruminants: Evaluation of Ipomoea carnea in Goats

Autor(es)

Gotardo, Andre T. ^[1] ; Schumaher, Breno H. ^[2] ; Pfister, James A. ^[3] ; Traldi, Anneliese S. ^[4] ; Maiorka, Paulo C. ^[1] ; Spinosa, Helenice S. ^[1] ; Gorniak, Silvana L. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, Res Ctr Vet Toxicol CEPTOX, BR-05508900 Sao Paulo - Brazil

^[2] Sch Vet Med, Super Baptist Sch Amazon ESBAM, Manaus, Amazonas - Brazil

^[3] ARS, USDA, Poisonous Plant Res Lab, Logan, UT - USA

^[4] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Anim Reprod, BR-05508900 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY; v. 95, n. 4, p. 289-295, AUG 2012.
• Citações Web of Science: 7

Resumo

Background: Ipomoea carnea (I. carnea) is a poisonous plant found in Brazil and other tropical countries that often poison livestock. The plant contains the alkaloids calystegines and mainly swainsonine, which inhibit cellular enzymes and cause systematic cell death. The objective of this study was to evaluate the perinatal effects of I. carnea in goats. Methods: Forty-seven pregnant goats were randomly allocated into 5 treatment groups and given the following doses (g/kg BW) of I. carnea: 0 (IC0), 1.0 (IC1), 3.0 (IC3), 5.0 (IC5) and 7.5 (IC7). The treatment animals were given fresh I. carnea from day 27 of gestation to parturition. Weight gains and serum biochemistry were evaluated. Fetuses were evaluated using ultrasonographic measurements. Results: Goats from the IC7 group showed clinical signs of poisoning. Ultrasound examination revealed that I. carnea feeding in all treatment groups reduced fetal movement compared to the controls. There was an increase in the total number of birth defects (retrognathia and arthrogyposis) in the IC7 and IC5 groups compared to the controls. Conclusion: The results show that I. carnea has teratogenic potential in goats. In addition, ultrasounds were useful in evaluating fetotoxicity and teratogenicity. Birth Defects Res (Part B) 00:17, 2012. (c) 2012 Wiley Periodicals, Inc. (AU)

• Processo FAPESP: 06/58729-2 - Estudo da toxicidade da Ipomoea carnea em caprinos durante o período perinatal. I. Avaliação dos possíveis efeitos lesivos no tecido placentário; II. Estudos de neuroteratologia
• Beneficiário: André Tadeu Gotardo
• Modalidade de apoio: Bolsas no Brasil - Mestrado