DTI voxelwise analysis did not differentiate older depressed patients from older subjects without depression

Autor(es)

Bezerra, Diana Moitinho ^[1] ; Pereira, Fabricio R. S. ^[2] ; Cendes, Fernando ^[2] ; Jackowski, Marcel Parolin ^[3] ; Nakano, Eduardo Y. ^[4] ; Moscoso, Marco A. A. ; Ribeiz, Salma R. I. ; Avila, Renata ; de Castro, Claudio Campi ^[5] ; Bottino, Cassio M. C.

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med, Inst & Dept Psychiat, Old Age Res Grp PROTER, BR-01060970 Sao Paulo - Brazil

^[2] Univ Campinas UNICAMP, Dept Neurol, Neuroimaging Lab, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Inst Math & Stat, BR-01060970 Sao Paulo - Brazil

^[4] Univ Brasilia UnB, Dept Stat, Brasilia, DF - Brazil

^[5] Univ Sao Paulo, Hosp Clin, Heart Inst InCor, Dept Diagnost Imaging, BR-01060970 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF PSYCHIATRIC RESEARCH; v. 46, n. 12, p. 1643-1649, DEC 2012.
• Citações Web of Science: 7

Resumo

Introduction: Neuroimaging has been widely used in studies to investigate depression in the elderly because it is a noninvasive technique, and it allows the detection of structural and functional brain alterations. Fractional anisotropy (FA) and mean diffusivity (MD) are neuroimaging indexes of the microstructural integrity of white matter, which are measured using diffusion tensor imaging (DTI). The aim of this study was to investigate differences in FA or MD in the entire brain without a previously determined region of interest (ROI) between depressed and non-depressed elderly patients. Method: Brain magnetic resonance imaging scans were obtained from 47 depressed elderly patients, diagnosed according to DSM-IV criteria, and 36 healthy elderly patients as controls. Voxelwise statistical analysis of FA data was performed using tract-based spatial statistics (TBSS). Results: After controlling for age, no significant differences among FA and MD parameters were observed in the depressed elderly patients. No significant correlations were found between cognitive performance and FA or MD parameters. Conclusion: There were no significant differences among FA or MD values between mildly or moderately depressed and non-depressed elderly patients when the brain was analyzed without a previously determined ROI. (C) 2012 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 04/09586-9 - Deficits cognitivos e alteracoes estruturais em exames de ressonancia magnetica: importancia para o desfecho da depressao em idosos.
• Beneficiário: Cássio Machado de Campos Bottino
• Modalidade de apoio: Auxílio à Pesquisa - Regular