| Texto completo | |
| Autor(es): |
Donato, Jr., J.
[1, 2, 3]
;
Lee, C.
[2]
;
Ratra, D. V.
[2]
;
Franci, C. R.
[4]
;
Canteras, N. S.
[1]
;
Elias, C. F.
[1, 2]
Número total de Autores: 6
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, BR-05508 Sao Paulo - Brazil
[2] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Div Hypothalam Res, Dallas, TX 75390 - USA
[3] Univ Sao Paulo, Dept Physiol & Biophys, Inst Biomed Sci, BR-05508 Sao Paulo - Brazil
[4] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Physiol, Ribeirao Preto, SP - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Neuroscience; v. 241, p. 67-79, JUN 25 2013. |
| Citações Web of Science: | 25 |
| Resumo | |
We have recently demonstrated that the ventral premammillary nucleus (PMV) plays a key role in the metabolic control of the female reproductive axis. However, whether PMV neurons modulate the reproductive neural circuitry and/or the expression of sexual behaviors has not been determined. Here, we showed that the expression of estrogen and progesterone receptors in the PMV is modulated by changing levels of sex steroids across the estrous cycle. We also showed that sexual behavior, not the high physiologic levels of sex steroids, induces Fos in PMV neurons. Bilateral lesions of the PMV caused no significant changes in proceptive behavior but a high percentage of PMV-lesioned rats failed to exhibit lordosis behavior when exposed to a sexually experienced male rat (50% vs. 18% in the control group). Notably, lesions of the PMV disrupted the physiologic fluctuations of Kiss1 and GnRH mRNA expression characteristic of the proestrus-to-estrus transition. This neurochemical imbalance may ultimately alter female reproductive behavior. Our findings suggest that the PMV is a component of the neural circuitry that modulates the physiologic fluctuations of key neuroendocrine players (i.e., Kiss1 and GnRH) in the control of the female reproductive physiology. (c) 2013 IBRO. Published by Elsevier Ltd. All rights reserved. (AU) | |
| Processo FAPESP: | 05/58997-4 - Papel do nucleo pre-mamilar ventral na regulacao da composicao corporal e da densidade ossea. |
| Beneficiário: | Jose Donato Junior |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 05/59286-4 - Bases neurais dos comportamentos motivados |
| Beneficiário: | Newton Sabino Canteras |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |