Carcinoma ex pleomorphic adenoma in a Brazilian population: clinico-pathological analysis of 38 cases

Autor(es)

Mariano, F. V. ^[1] ; Noronha, A. L. F. ^[1] ; Gondak, R. O. ^[1] ; Altemani, A. M. de A. M. ^[2] ; de Almeida, O. P. ^[1] ; Kowalski, L. P. ^[3]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Oral Diag, Sao Paulo - Brazil

^[2] Univ Estadual Campinas, Fac Med Sci, Dept Pathol, Sao Paulo - Brazil

^[3] AC Camargo Hosp, Dept Head & Neck & Otorhinolaryngol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: International Journal of Oral and Maxillofacial Surgery; v. 42, n. 6, p. 685-692, JUN 2013.
• Citações Web of Science: 18

Resumo

Carcinoma ex pleomorphic adenoma (CXPA) is a rare tumour, with different prevalence rates reported among studies. Epidemiological studies of large series of CXPAs in developing countries are scarce. The aim of the present study was to describe Brazilian patients with CXPA CXPA; this was a retrospective study of 38 patients. Demographic and clinico-pathological features were evaluated. No preferential gender was found, and the mean age at diagnosis was 57.6 years. The most commonly involved site was the parotid, followed by the submandibular and the minor salivary glands. A prevalence of clinical stages III and IV was observed at diagnosis. The most common histological subtypes were salivary duct carcinoma, adenocarcinoma not otherwise specified, myoepithelial carcinoma, and epithelial myoepithelial carcinoma. Moreover, by invasive phase, most were frankly invasive carcinoma. Recurrence was observed in seven out of 24 patients with outcome information available, and all were invasive cases. All seven patients died of causes related to the disease. The distributions of cases according to age, gender, tumour location, and clinical stage were similar to those reported in the literature. Frankly invasive cases presented a worse prognosis. More information is needed to further our understanding of the clinico-pathological aspects of CXPA. (AU)

• Processo FAPESP: 11/23204-5 - Estudo do perfil genômico do carcinoma ex-adenoma pleomorfo por hibridização genômica comparativa em microarranjo (CGH array)
• Beneficiário: Albina Messias de Almeida Milani Altemani
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/23366-5 - Estudo do perfil genômico do carcinoma ex-adenoma pleomorfo por hibridização genômica comparativa em microarranjo (CGH array)
• Beneficiário: Fernanda Viviane Mariano Brum Corrêa
• Linha de fomento: Bolsas no Brasil - Pós-Doutorado