Effects of selenium on Pteridium aquilinum and urethane-induced lung carcinogenesis

Autor(es)

Nakahara, Sheila B. R. ^[1] ; Sanches, Daniel S. ^[1] ; Caniceiro, Beatriz D. ^[1] ; Wysochi, Jr., Harry L. ^[2] ; da Silva, Graziela B. ^[3] ; Latorre, Andreia O. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, BR-05508270 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Lab Farmacognosia, Fac Ciencias Farmaceut, BR-05508270 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Lab Hematol, Fac Ciencias Farmaceut, BR-05508270 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Immunopharmacology and Immunotoxicology; v. 35, n. 5, p. 605-614, OCT 2013.
• Citações Web of Science: 5

Resumo

The results of our previous study demonstrated that ptaquiloside, the main toxic agent found in Pteridium aquilinum, suppresses natural killer (NK) cell-mediated cytotoxicity. However, the ability of ptaquiloside to suppress the cytotoxicity of NK cells was prevented by selenium supplementation. NK cells play an important role in the innate immune response and have the ability to kill tumor cells. Therefore, we hypothesized that selenium may prevent the higher susceptibility to urethane-induced lung carcinogenesis that has been observed in mice treated with P. aquilinum. The immunosuppressive effects of ptaquiloside have been associated with a higher number of urethane-induced lung nodules in mice. Hence, we assessed the effects of P. aquilinum-induced immunosuppression on urethane-induced lung carcinogenesis in C57BL/6 mice that had been supplemented with selenium. For these experiments, mice were treated with both an aqueous extract of P. aquilinum (20 g/kg/day) and selenium (1.3 mg/kg) by gavage once daily for 14 days followed by a once-weekly intraperitoneal injection of urethane (1 g/kg) for 10 weeks that was accompanied by gavage 5 days a week. Lung adenomas in mice that had been treated with P. aquilinum plus urethane occurred with a frequency that was 44% higher than that in mice that had been treated with only urethane. In mice that had been supplemented with selenium and treated with P. aquilinum plus urethane, the occurrence of lung adenomas was reduced to 26%. These results suggest that selenium prevents the immunosuppressive effects of P. aquilinum on urethane-induced lung carcinogenesis. (AU)

• Processo FAPESP: 10/52186-2 - I. avaliacao dos mecanismos moleculares da imunotoxicidade e carcinogenicidade da pteridium aquilinum. ii. avaliacao do mecanismo de reversao da imunotoxicidade pela suplementacao com selenio
• Beneficiário: Andréia Oliveira Latorre
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado