Chemical composition, antischistosomal and cytotoxic effects of the essential oil of Lavandula angustifolia grown in Southeastern Brazil

Autor(es)

André L.L. Mantovani ^[1] ; Geovana P.G. Vieira ^[2] ; Wilson R. Cunha ^[2] ; Milton Groppo ^[3] ; Raquel A. Santos ^[2] ; Vanderlei Rodrigues ^[4] ; Lizandra G. Magalhães ^[7] ; Antônio E.M. Crotti

Afiliação do(s) autor(es)

^[1] Universidade de Franca. Núcleo de Pesquisas em Ciências Exatas e Tecnológicas - Brasil

^[2] Univ Franca, Nucleo Pesquisas Ciencias Exatas & Tecnol, Franca, SP - Brazil

^[3] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Biol, Ribeirao Preto, SP - Brazil

^[4] Univ Sao Paulo, Fac Med Ribeirao Preto, BR-14049 Ribeirao Preto, SP - Brazil

^[5] Universidade de Franca. Núcleo de Pesquisas em Ciências Exatas e Tecnológicas - Brasil

• Tipo de documento: Artigo Científico
• Fonte: REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY; v. 23, n. 6, p. 877-884, 2013-12-00.

Resumo

This paper reports on the chemical composition, the in vitroantischistosomal effects, and the cytotoxicity of the essential oil from the leaves of Lavandula angustifolia Mill., Lamiaceae, grown in the Southeastern Brazil. Borneol (22.4%), epi-α-muurolol (13.4%), α-bisabolol (13.1%), precocene I (13.0%), and eucalyptol (7.9%) were the major essential oil constituents. Incubation with essential oil at 200 μg/ml killed all the adult S. mansoni worms after 24 h (LC50117.7 and 103.9 μg/ml at 24 and 120 h of incubation, respectively). At a concentration of 50 μg/ ml, the essential oil significantly decreased the motor activity and reduced the percentage of egg development after 120 h. In addition, the essential oil separated all the coupled S. mansoni worm pairs into individual male and female at 25 and 50 μg/ml within 120 and 24 h, respectively. This oil was cytotoxic to GM07492-A cells at only concentrations higher than 200 µg/ml (IC50243.7 µg/ml). These data indicate that LA-EO exhibits moderate in vitro activity against adult S. mansoniand exerts remarkable effects on eggs development. (AU)

• Processo FAPESP: 09/15207-4 - Avaliação do efeito de lignanas e neolignanas em Schistosoma mansoni: uma abordagem proteômica
• Beneficiário: Lizandra Guidi Magalhães
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 07/54241-8 - Prospecção de óleos essenciais de espécies brasileiras cultiváveis com atividade contra patógenos da cavidade bucal
• Beneficiário: Antônio Eduardo Miller Crotti
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Jovens Pesquisadores