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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Mannose-binding lectin gene polymorphism and risk factors for cardiovascular disease in postmenopausal women

Texto completo
Autor(es):
Orsatti, Claudio Lera [1] ; Petri Nahas, Eliana Aguiar [1] ; Nahas-Net, Jorge [1] ; Orsatti, Fabio Lera [2] ; Linhares, Iara Moreno [3] ; Witkin, Steven Sol [4]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ UNESP, Botucatu Med Sch, Dept Gynecol & Obstet, BR-18618970 Botucatu, SP - Brazil
[2] Inst Hlth Sci UFTM, Dept Sports Sci, Uberaba, MG - Brazil
[3] Univ Sao Paulo, Sch Med, Dept Gynecol & Obstet, Sao Paulo - Brazil
[4] Weill Cornell Med Coll, Div Immunol & Infect Dis, Dept Obstet & Gynecol, New York, NY - USA
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: Molecular Immunology; v. 61, n. 1, p. 23-27, SEP 2014.
Citações Web of Science: 5
Resumo

Background: Inflammatory responses may be altered in postmenopausal women and predispose to cardiovascular disease (CVD). Genetic factors can also influence susceptibility to CVD. Mannose-binding lectin (MBL) is a component of the innate immune system and an activator of the complement cascade. We evaluated the association of genetic polymorphism of MBL (MBL2) on risk factors for CVD in postmenopausal women. Methods: In this cross-sectional study, 311 Brazilian women (age >= 45 years and amenorrhea >= 12 months) were included. Exclusion criteria: presence of previous or current CVD, insulin dependent diabetes, chronic kidney disease, autoimmune diseases and cancer. Clinical, anthropometric and biochemical assessments were performed to evaluate the cardiovascular risk factors. DNA was extracted from buccal cell and polymorphisms at codons 54 and 57 in the MBL2 were determined by polymerase chain reaction (PCR). For statistical analysis, the chi-square and logistic regression (odds ratio, OR) were used. Results: The presence of the polymorphic allele for codon 54 was found in 25.8% of women (A/B = 22.6%, B/B = 3.2%) and for codon 57 in 12.2% (A/C = 10.8%, C/C = 1.4%). The polymorphism at codon 54 was significantly associated with the presence of hypertension (OR 0.55, 95% CI 0.31-0.99, p = 0.044) and insulin resistance assessed by HOMA-IR (OR 0.46, 95% CI 0.24-0.91, p = 0.025). No significant associations were observed between the polymorphism at codon 57 with risk factors for CVD. Conclusion: In postmenopausal women, the polymorphism at cation 54 of the MBL2 was associated with lower risk for hypertension and insulin resistance that are important risk factors for CVD. (C) 2014 Published by Elsevier Ltd. (AU)

Processo FAPESP: 09/14884-2 - Avaliação dos biomarcadores precoces da doença cardiovascular - clínicos, inflamatórios e ecográficos - em mulheres na pós-menopausa
Beneficiário:Eliana Aguiar Petri Nahás
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 09/18256-6 - Avaliação do polimorfismo genético da lecitina ligante de manose, da expressão gênica dos receptores Toll-Like e do perfil de citocinas como bio-marcadores do risco cardiovascular em mulheres na pós-menopausa
Beneficiário:Cláudio Lera Orsatti
Linha de fomento: Bolsas no Brasil - Doutorado