| Texto completo | |
| Autor(es): |
Alves Souza, Rodrigo Wagner
[1]
;
Aguiar, Andreo F.
[1, 2]
;
Vechetti-Junior, Ivan J.
[1]
;
Piedade, Warlen Pereira
[1]
;
Rocha Campos, Gerson Eduardo
[3]
;
Dal-Pai-Silva, Maeli
[1]
Número total de Autores: 6
|
| Afiliação do(s) autor(es): | [1] Sao Paulo State Univ UNESP, Dept Morphol, Sao Paulo - Brazil
[2] North Univ Parana UNOPAR, Ctr Biol & Hlth Sci, Londrina, Parana - Brazil
[3] Univ Estadual Campinas, Dept Anat Cell Biol Physiol & Biophys, Sao Paulo - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF STRENGTH AND CONDITIONING RESEARCH; v. 28, n. 8, p. 2338-2345, AUG 2014. |
| Citações Web of Science: | 7 |
| Resumo | |
The aim of this study was to investigate the effects of a resistance training program with excessive training load and insufficient recovery time between bouts on muscle hypertrophy-and atrophy-related protein expression. Male Wistar rats were randomly assigned to either a trained (TR, N = 9) or a sedentary (SE, N = 9) group. The TR group was subjected to a 12-week resistance training program with excessive training load and insufficient recovery between bouts that was designed to induce plantaris muscle atrophy. After the 12-week experiment, the plantaris muscle was collected to analyze the cross-sectional area (CSA) of the muscle fibers, and MAFbx, MyoD, myogenin, and IGF-I protein expression (Western blot). The CSA was reduced significantly (-17%, p <= 0.05) in the TR group compared with the SE group. Reciprocally, there was a significant (p <= 0.05) 20% increase in MAFbx protein expression, whereas the MyoD (-27%), myogenin (-29%), and IGF-I (-43%) protein levels decreased significantly (p <= 0.05) in the TR group compared with the SE group. In conclusion, our data indicated that muscle atrophy induced by resistance training with excessive training load and insufficient recovery was associated with upregulation of the MAFbx catabolic protein and downregulation of the MyoD, myogenin, and IGF-I anabolic proteins. These findings suggest that quantitative analysis of these proteins can be important and complementary with other biochemical markers to confirm a possible overtraining diagnosis. (AU) | |
| Processo FAPESP: | 08/52641-1 - Morfologia e expressao dos fatores de regulacao miogenica (mrfs) e igf-1 no musculo esqueletico de ratos submetidos ao treinamento resistido. |
| Beneficiário: | Rodrigo Wagner Alves de Souza |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |