Antidepressant like effects of deep brain stimulation in rats and the hypothalamic, pituitary, adrenal axis

• Processo: 11/51815-9
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Data de Início da vigência: 01 de abril de 2012
• Data de Término da vigência: 31 de março de 2014
• Área do conhecimento: Ciências Biológicas - Fisiologia - Fisiologia de Órgãos e Sistemas
• Acordo de Cooperação: Universidade de Toronto e Universidade de Western Ontario
• Pesquisador responsável: Luciene Covolan
• Beneficiário: Luciene Covolan
• Pesquisador Responsável no exterior: Clement Hamani
• Instituição Parceira no exterior: University of Toronto (U of T), Canadá
• Instituição Sede: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brasil
• Assunto(s): Estimulação cerebral Estresse Sistema hipófise-suprarrenal
• Palavra(s)-Chave do Pesquisador: Behavior | Chronic Stress | Deep Brain Stimulation | Surgery

Resumo

Deep brain stimulation involves the implantation of electrodes into the brain thorough current is delivered to specific targets in patients with depression, promising results have been reported with DBS at different site, including the subgenual cingulated gyrus (SCG) TO investigate mechanisms of this therapy, we have recently studied the effects of DBS in the rodent homologue of the SCG, the ventromedial prefrontal cortex (vmPFC). In a recent collaborative study between the University of Toronto/Centre for Addiction and Mental Health and the Universidade Federal de São Paulo, we have recently shown an important antianhedonic/antidepressant-like effect of vmPFC DBS in rais undergoing chronic unpredictable mild stress (CUS). In this proposal we will test the hypotheses that 1) DBS will improve a series of tests to measure depressive and anxiely like behavioral in animals undergoing CUS and 2) DBS will reverse stress-induced changes in the hypothalamic pituitary andrenal (IIPA) axis, Patients with depression have levels of corticosterone Chronic stress and hypercortisolemia are often deleterious from a health perspective Results from experiments in this proposal may pave the way for future investigation to assess whether DBS nay improve the consequences of hypercortisolemia and stress. (AU)