Is there a salivary biomarker for periodontitis associated with weight reduction therapies?

• Processo: 12/50580-0
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Data de Início da vigência: 01 de outubro de 2012
• Data de Término da vigência: 30 de setembro de 2014
• Área do conhecimento: Ciências da Saúde - Odontologia
• Acordo de Cooperação: King's College London
• Pesquisador responsável: Silvia Helena de Carvalho Sales Peres
• Beneficiário: Silvia Helena de Carvalho Sales Peres
• Pesquisador Responsável no exterior: Guy Carpenter
• Instituição Parceira no exterior: King's College London, Inglaterra
• Instituição Sede: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brasil
• Vinculado ao auxílio: 10/09951-0 - Avaliação in vitro do potencial de um gel contendo Euclea natalensis na redução da erosão dentária e na permeabilidade dentinária, AP.R
• Assunto(s): Obesidade Cirurgia bariátrica Doenças periodontais Saliva Biomarcadores
• Palavra(s)-Chave do Pesquisador: Bariatric Patients | Biological Markers | Obsety | Periodontal Disease | Salivary Biomarkers

Resumo

In a previous study patients undergoing bariatric surgery for obesity reduction have gone on to develop periodontitis Sales Peres (submitted). There is a need therefore to identify patients likely to develop periodontitis to monitor and treat the gum disease. Salivary biomarkers of periodontitis will be assessed longitudinally to determine response to bypass surgery. The study was distributed into 2 groups: CG- normal weight (n=30); COG- morbid obese (n=87). These patients were followed up after surgery: EB6- 6 months (n=55); EB12-12 months (n=43). Clinical measures of periodontal disease (bleeding on probing-BOP, presence of calculus-PC, probing depth-PD and clinical attachment loss-CAL) and saliva collection (stimulate saliva) were recorded at each visit (month 0, 6 and 12). In this study saliva samples will be analysed for by a proteomic approach (MALDI MS/MS) to determine potential markers for obesity. Since saliva samples have been collected before surgery it may be possible to discover a marker for susceptibility to periodontitis- something that cannot be achieved with patients already presenting with periodontitis. (AU)