The transcriptome of a mouse model of aggression

• Processo: 01/09079-1
• Modalidade de apoio: Bolsas no Brasil - Jovens Pesquisadores
• Data de Início da vigência: 01 de outubro de 2001
• Data de Término da vigência: 30 de setembro de 2005
• Área de conhecimento: Ciências da Saúde - Medicina - Psiquiatria
• Pesquisador responsável: Silvana Chiavegatto
• Beneficiário: Silvana Chiavegatto
• Instituição Sede: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brasil
• Vinculado ao auxílio: 01/01637-5 - Transcritoma da agressão em um modelo animal, AP.JP
• Assunto(s): Comportamento agressivo Cérebro Expressão gênica
• Palavra(s)-Chave do Pesquisador: Agressao | Camundongo | Cerebro | Expressao Genica

Resumo

Human aggression is clearly an important issue for our society. Through research over the past two decades, it has become clear that human aggression is not simply "bad behavior" and that problematic impulsive aggression can be viewed as an identifiable behavioral disorder with genetic, biological, and treatment correlates. Aggression as complex behaviors probably depend on many genetic points, disruptions in any of these can lead to dysfunctional outcomes. The challenge then comes from the demands for high-throughput assays to investigate the global gene expression in order to identify the genes and gene products that work in concert to modulate the expression of the aggressive behavior. Neurobehavioral studies have advanced substantially through the use of mouse genetics. We therefore propose to apply gene expression profiling of multiple brain regions in groups of adult male mice that differ in their responsiveness to an intruder in their home cages (mouse model of aggression). We will use the new DNA microarray technology, which allows for the study of expression patterns of a large number of genes simultaneously within a brain area, as an efficient means of gaining critical insights to the expression, regulation, and function of genes involved in mammalian aggressive behavior for which information is currently scarce. (AU)