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METHODS OF PHSYCOCHEMICAL-GUIDED PEPTIDE DESIGN AND NOVEL PEPTIDES DERIVED THEREFROM
| Tipo de documento: | Patente |
| Inventor(es): | LU, Timothy Kuan-Ta; DE LA FUENTE NUNEZ, Cesar; DE OLIVEIRA JUNIOR, Vani Xavier; DER TOROSSIAN TORRES, Marcelo |
| Depositante: | Massachusetts Institute of Technology (MIT) ; Universidade Federal do ABC (UFABC) |
| Data do depósito: | 21 de setembro de 2018 |
| Registro INPI: | |
| IPC: | A61P 31/00 C07K 14/00 A61K 38/10 |
Resumo
Described herein are methods of psychochemical-guided peptide design that utilize specific functional determinants to a protein's property of interest. Also described herein are novel synthetic peptide antibiotics that have increased potency and/or decreased toxicity relative to the template peptide from which they were derived, and methods of use thereof in treating microbial infections.
| Processo FAPESP: | 17/03046-2 - Peptídeos biologicamente ativos em micro-organismos patogênicos e em células tumorais |
| Beneficiário: | Vani Xavier de Oliveira Junior |
| Pesquisador responsável: | Vani Xavier de Oliveira Junior |
| Instituição: | Universidade Federal do ABC (UFABC). Centro de Ciências Naturais e Humanas (CCNH) |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |