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METHODS OF PHSYCOCHEMICAL-GUIDED PEPTIDE DESIGN AND NOVEL PEPTIDES DERIVED THEREFROM
| Document type: | Patente |
| Inventor(s): | LU, Timothy Kuan-Ta; DE LA FUENTE NUNEZ, Cesar; DE OLIVEIRA JUNIOR, Vani Xavier; DER TOROSSIAN TORRES, Marcelo |
| Applicant: | Massachusetts Institute of Technology (MIT) ; Universidade Federal do ABC (UFABC) |
| Deposit date: | September 2018, 21 |
| INPI register: | |
| IPC: | A61P 31/00 C07K 14/00 A61K 38/10 |
Abstract
Described herein are methods of psychochemical-guided peptide design that utilize specific functional determinants to a protein's property of interest. Also described herein are novel synthetic peptide antibiotics that have increased potency and/or decreased toxicity relative to the template peptide from which they were derived, and methods of use thereof in treating microbial infections.
| FAPESP's process: | 17/03046-2 - Biologically active peptides against pathogenic microorganisms and cancer cells |
| Grantee: | Vani Xavier de Oliveira Junior |
| Principal Investigator: | Vani Xavier de Oliveira Junior |
| Institution: | Universidade Federal do ABC (UFABC). Centro de Ciências Naturais e Humanas (CCNH) |
| Support Opportunities: | Regular Research Grants |