The purpose of the Young Investigator Grant (JP) is to support a scientifically sound and high-quality research project. It also aims to encourage the attraction, under internationally competitive conditions, of young researchers with demonstrated international postdoctoral research experience who are still in the process of establishing their professional careers, to research institutions in the State of São Paulo.
The purpose of the Young Investigator Grant Phase 2 (JP-2) is to enable the consolidation of research lines initiated by applicants who have previously received a highly successful Young Investigator Grant (JP) from FAPESP.
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The Laboratory of Ecology and Evolution (LEEv), based at the Instituto Butantan, plays a central role in developing integrative approaches to understanding species ecology and evolution. Recently, LEEv inaugurated a state-of-the-art laboratory complex dedicated to conservation and education, consolidating Butantan's leadership in conservation science in South America. This proposal aims t…
Molecular rotors are molecular systems in which a molecule or part of a molecule rotates against another or against a macroscopic entity such as a surface or a solid. The restriction of intramolecular motions dramatically increases the photoluminescence properties of these small molecules in rigid environments or in solid state. In this proposal, the design, synthesis, and photoluminescen…
This proposal aims to understand the molecular and cellular mechanisms that modulate immune responses to vaccines developed or prioritized by Instituto Butantan (e.g., dengue, Zika, yellow fever, influenza, pneumococcus, and COVID-19), and how these mechanisms are influenced by factors such as age, sex, and prior exposures. Combining a mechanistic perspective in immunology with computatio…
(Only some records are available in English at this moment)
The proposed research will concentrate on developing novel directions and techniques for the analysis of annihilation, branching, coalescent, and related stochastic processes. We will work on problems involving random self-similar trees and their applications, including hydrology and statistical seismology. We will explore vector-multiplicative coalescent processes and their connections t…
Snake venoms contain a complex mixture of tissue-damaging toxins that compromise the architecture, functional capacity, and mobility of skeletal muscles. Brazilian snake venoms, particularly those from Bothrops jararaca and Bothrops atrox, are rich in proteins that exert direct effects on muscle cells, break down the surrounding extracellular microenvironment and destabilise the vascular …
Despite recent progress towards elimination, malaria is still one of the main causes of morbidity and mortality in tropical and subtropical regions, with around 263 million cases a year. In recent decades, successful efforts, such as the expansion of vector control strategies and the implementation of important diagnostic and treatment measures, have led to a significant decrease in malar…
(Only some records are available in English at this moment)
Understanding how light induces chemical transformations at the molecular level is key to developing photochemical reactions that underlie the design of novel compounds and materials. In this Young Investigator project, we propose to investigate molecular reactivity concepts that enable the structural, magnetic, and mechanistic understanding of light-driven processes. Aim 1 explores the c…
The main objective of this project is to investigate the formation and evolution of accreting white dwarfs using numerical simulations. The study of accreting white dwarfs bears relevance for several fields of research due to their wide variety of phenomena, over virtually all wavelengths and on a broad range of timescales, which makes them natural laboratories to investigate, for instanc…
Nitrate contamination is almost ubiquitous in urban unconfined aquifers, becoming a challenge for the São Paulo State where more than 80% of its municipalities are supplied totally or partially by groundwater. Despite the several existing studies, there are critical scientific challenges that overcoming will contribute to the environmental management of extensive contaminated urban areas.…
(Only some records are available in English at this moment)
Os venenos de serpentes contêm uma mistura complexa de toxinas que causam danos teciduais, comprometendo a arquitetura, capacidade funcional e mobilidade dos músculos esqueléticos. Os venenos de serpentes brasileiras, especialmente Bothrops jararaca e Bothrops atrox, são ricos em proteínas que exercem efeitos diretos sobre as células musculares, degradam o microambiente extracelular circu…
A transmissão de informações entre gerações é um princípio fundamental da biologia, mediada pela herança de diferentes tipos de moléculas. Entre elas, encontram-se os RNAs pequenos, um tipo de RNA não codificante com cerca de 20 a 30 nucleotídeos que modula a expressão dos RNAs mensageiros alvo, geralmente promovendo seu silenciamento. A distribuição de RNAs pequenos herdados entre as cél…
Aproximadamente 80% da energia produzida no mundo é obtida a partir de combustíveis fósseis. Portanto, uma migração gradual para um sistema de energia mais sustentável é uma demanda da atualidade. A bioenergia pode colaborar com esse novo sistema por meio da produção de biometano. Resíduos sólidos orgânicos, se gerenciados inadequadamente, contribuem para o emissão de gases do efeito estu…
(Only some records are available in English at this moment)
Entender como a luz induz transformações químicas a nível molecular é fundamental para o desenvolvimento de reações fotoquímicas que sustentam o planejamento de novos compostos e materiais. Neste projeto de Jovem Pesquisador propomos investigar conceitos de reatividade molecular que possibilitem uma compreensão estrutural, magnética e mecanística de processos impulsionados pela luz. No su…
Sabe-se que os hormônios sexuais interagem com o sistema imunológico em vários níveis, uma vez que foram encontrados receptores de hormônios sexuais (SHRs) em vários tipos de células imunológicas, incluindo células mononucleares. No entanto, não está claro como o nível de aptidão física pode controlar a resposta inflamatória em mulheres em diferentes fases da vida reprodutiva. Nesse senti…
O principal objetivo deste projeto é investigar a formação e evolução de anãs brancas acretantes com simulações numéricas. O estudo das anãs brancas acretantes é relevante para diversos campos de pesquisa devido à sua grande variedade de fenômenos, em praticamente todos os comprimentos de onda e em uma ampla gama de tempos de escala, o que as torna laboratórios naturais para investigar, p…
(Only some records are available in English at this moment)
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