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IMMUNOGENIC COMPLEX FORMED BY VACCINAL ANTIGENS ENCAPSULATED BY NANOSTRUCTURED MESOPOROUS SILICA

EscritórioCIPC
Tipo de documento:Patente
Inventor(es): Ogari De Castro Pacheco; Osvaldo Augusto Brazil Esteves Sant'Anna; Lucildes Pita Mercuri; Jivaldo Do Rosário Matos; Marcia Carvalho De Abreu Fantini
Resumo

The present invention relates to an "immunogenic complex" product comprising an adjuvant characterized by solid particles of highly ordered nanostructured mesoporous silica, preferably SBA-15 antigenic silica of various natures encapsulated in said adjuvants. The immunogenic complex of the present invention allows the presentation of the antigen that composes it to lymphocytes in a safe, gradual and prolonged way that leads to a more efficient immunological memory, increases antigen immunogenicity and improves antibody production. This ensures efficient immunological protection with lower antigen amounts and / or fewer repeat vaccine doses. Furthermore, the characteristics of the immunogenic complex of the present invention promote effective homogeneous induction of immunity in "good and bad responders" individuals.


Processo FAPESP: 04/11597-9 - Estudo experimental do efeito adjuvante da silica nanoestruturada sba-15.
Beneficiário:Luciana Vieira Carvalho
Pesquisador responsável:Osvaldo Augusto Brazil Esteves Sant'Anna
Instituição: Secretaria da Saúde (São Paulo - Estado). Instituto Butantan
Modalidade de apoio: Bolsas no Brasil - Mestrado