IMMUNOGENIC COMPLEX FORMED BY VACCINAL ANTIGENS ENCAPSULATED BY NANOSTRUCTURED MESOPOROUS SILICA
| Office | CIPC |
| Document type: | Patent |
| Inventor(s): | Ogari De Castro Pacheco; Osvaldo Augusto Brazil Esteves Sant'Anna; Lucildes Pita Mercuri; Jivaldo Do Rosário Matos; Marcia Carvalho De Abreu Fantini |
| Applicant: | Cristália Produtos Químicos Farmacêuticos Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) |
| Year: | 2006 |
| Application Number: | ZA 2008/02277 |
| IPC: | A61K 39/39 |
The present invention relates to an "immunogenic complex" product comprising an adjuvant characterized by solid particles of highly ordered nanostructured mesoporous silica, preferably SBA-15 antigenic silica of various natures encapsulated in said adjuvants. The immunogenic complex of the present invention allows the presentation of the antigen that composes it to lymphocytes in a safe, gradual and prolonged way that leads to a more efficient immunological memory, increases antigen immunogenicity and improves antibody production. This ensures efficient immunological protection with lower antigen amounts and / or fewer repeat vaccine doses. Furthermore, the characteristics of the immunogenic complex of the present invention promote effective homogeneous induction of immunity in "good and bad responders" individuals.
| Grantee: | Luciana Vieira Carvalho |
| Principal Investigator: | Osvaldo Augusto Brazil Esteves Sant'Anna |
| Institution: | Secretaria da Saúde (São Paulo - Estado). Instituto Butantan |
| Support Opportunities: | Scholarships in Brazil - Master |