Paulo Roberto das Dores da Silva

Dr. Paulo Roberto Dores-Silva is a biophysicist and structural biologist with over 15 years of experience advancing protein structure/function and drug discovery across academia and industry. Currently serving as Senior Scientist - Biophysics at Ferring Ventures in San Diego, he leads critical efforts in biophysical assay development, protein production, and structure-function analysis, having characterized over 40 recombinant proteins and enabled medicinal chemistry campaigns across multiple therapeutic areas. His work integrates state-of-the-art techniques such as SPR, MST, DSF, ITC, HDX-Mass and cryo-EM to support hit identification, hit-to-lead optimization, and ligand screening for fragments, small molecules, antibodies, and peptides. He has contributed to innovative strategies for radiotherapeutic protein conjugation and linker design. Previously at Ferring Research Institute, he established robust biophysics workflows and screening platforms that accelerated fragment-based lead discovery. Dr. Dores-Silva's postdoctoral research at the University of California, San Diego focused on the molecular mechanisms of mitochondrial chaperones in membranes and beta-amyloid oligomerization, following earlier work at the University of São Paulo, where he also earned his Ph.D. in in Organic and Biological Chemistry and B.Sc. in Analytical Chemistry. Author of 36 peer-reviewed publications and recipient of the Experimental Biology Medicine Outstanding Reviewer Award (2021), he is recognized for scientific rigor, innovation, and mentorship. He is a permanent U.S. resident. (Fonte: Currículo Lattes)