AMH: An ovarian reserve biomarker in assisted reproduction

Autor(es)

Peluso, C. ^[1] ; Fonseca, F. L. A. ^[2] ; Rodart, I. F. ^[1] ; Cavalcanti, V. ^[1] ; Gastaldo, G. ^[1] ; Christofolini, D. M. ^[1] ; Barbosa, C. P. ^[1] ; Bianco, B. ^[1]

Afiliação do(s) autor(es)

^[1] Fac Med ABC, Dept Collect Hlth, Human Reprod & Genet Ctr, Santo Andre, SP - Brazil

^[2] Fac Med ABC, Dept Clin Med, Clin Lab, Santo Andre, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Clinica Chimica Acta; v. 437, p. 175-182, NOV 1 2014.
• Citações Web of Science: 35

Resumo

Ovarian reserve tests provide knowledge of a possible response to controlled ovarian hyperstimulation in patients undergoing assisted reproduction treatment, allowing management and alteration of treatment protocol with the appropriate dose of gonadotrophin. Several parameters have been used as predictors of ovarian response. The basal FSH serum level on the third day of the menstrual cycle seemed to be the best predictor, but with significant intraindividual variability from one cycle to another. Thus, the anti-Mullerian hormone (AMH) emerges as a new ovarian test marker. AMH is produced exclusively in the gonads, by the granulosa cells, and plays an important role in folliculogenesis, acting on the modulation of follicular recruitment in the granulosa cells in order to limit the number of recruited oocytes and to regulate the number of growing follicles and their selection for ovulation. It has been suggested that AMH is strongly associated with oocyte yield after ovarian stimulation and could therefore be capable of predicting the ovarian response and the quality of oocytes and embryos. In this review, we discuss the role of AMH in assisted reproduction outcomes. (C) 2014 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 11/15045-4 - Avaliação de polimorfismos dos genes Amh e AMHR2 em mulheres inférteis e sua correlação com resultados de reprodução assistida
• Beneficiário: Carla Peluso de Paiva
• Linha de fomento: Bolsas no Brasil - Mestrado
• Processo FAPESP: 11/08681-1 - Avaliação de polimorfismos do gene FSHr, Amh e AMHR2 em mulheres inférteis e sua correlação com resultados de reprodução assistida
• Beneficiário: Bianca Alves Vieira Bianco
• Linha de fomento: Auxílio à Pesquisa - Regular