Prospective evaluation of cytokine in saliva of preterm and fullterm neonates

Autor(es)

Talarico Sesso, Maria Lucia ^[1] ; Loureiro Borges, Mariana Castro ^[1] ; Leme Ferriani, Virginia Paes ^[1] ; Geraldo-Martins, Vinicius Range ^[2] ; Rocha Rodrigues, Denise Bertulucci ^[2] ; Nogueira, Ruchele Dias ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Med Sch Ribeirao Preto, Dept Pediat, Sao Paulo - Brazil

^[2] Univ Uberaba, Uberaba, MG - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Immunobiology; v. 219, n. 11, p. 830-835, NOV 2014.
• Citações Web of Science: 2

Resumo

Little is known about the ontogeny of the cytokines in saliva of newborn. Previous studies showed that levels of immunoglobulin A (IgA) in saliva could be influenced by prematurity. So, the aim of this study was to analyze the levels of interleukin 6 (IL-6), interleukin 10 (IL-10), interleukin 12 (IL-12), and interferon gamma (IFN-gamma) in sample saliva of fullterm (FT) and preterm (PT) neonates at birth (TO) and after 3 months of age (T3). Saliva from 50 infants (25 FT and 25 PT) were collected at TO and T3 and analyzed by Luminex Corporation (Austin, Texas, United States) multiplex assay. Clinical characteristics and social-economic data were assessed through questionnaires. All cytokines could be detected at birth in levels higher than found in T3. The mean levels and frequency of detection of cytokines were significantly higher in PT than FT at TO (P < 0.05). There were a positive association between IL-10 and infection (P < 0.05) and IL-6 and stress (P < 0.005). Salivary cytokines were detected within the first hours after birth and their levels decreased after 3. months. The cytokine levels were different between PT and FT children and appear to be influenced by stress situation and/or antigenic microbial challenge. The results confirm the necessity for further studies about the mucosal immune system by using of saliva as a source of diagnostic by identification of biomarkers of the status of the immune. (C) 2014 Elsevier GmbH. All rights reserved. (AU)

• Processo FAPESP: 07/57346-5 - Resposta imune de mucosas em nascidos pre-termo (pt) e de baixo peso ao nascer (bpn).
• Beneficiário: Virginia Paes Leme Ferriani
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 07/50807-7 - Resposta imune de mucosas em nascidos pre-termo (pt) e de baixo peso ao nascer (bpn).
• Beneficiário: Ruchele Dias Nogueira
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado