Two-year randomized clinical trial of enamel matrix derivative treated infrabony defects: radiographic analysis

Autor(es)

Ragghianti Zangrando, Mariana Schutzer ^[1] ; Chambrone, Daniela ^[1] ; Pasin, Ivan Munhoz ^[1] ; Conde, Marina Clemente ^[1] ; Pannuti, Claudio Mendes ^[1] ; Pugliesi Alves de Lima, Luiz Antonio ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Dent, BR-05508000 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BMC ORAL HEALTH; v. 14, DEC 4 2014.
• Citações Web of Science: 1

Resumo

Background: This split-mouth, double-blind randomized controlled trial evaluated radiographic changes in infrabony defects treated with open flap debridement (OFD) or OFD associated with enamel matrix derivative (EMD) after a 24-month follow-up. The radiographic distance from the CEJ to the bottom of the defect (BD) was considered the primary outcome. CEJ-BC and defect angle were secondary outcomes. Methods: Ten patients presenting 2 or more defects were selected. An individualized film holder was used to take standardized radiographs of the 43 defects, at baseline and after 24 months. Images were digitized and used to measure the distances from the cemento-enamel junction (CEJ) to the alveolar crest (AC), CEJ to the bottom of the defect (BD) and infrabony defect angle. Statistical analysis was performed in SPSS for Windows (version 5.2). Paired samples t test was used to compare test and control groups and to evaluate changes within each group. The level of significance was set at alpha = 0.05%. Results: After 24 months, a significant crestal bone loss was observed for EMD (1.01 mm; p = 0.049) but not for OFD (0.14 mm; p = 0.622). However, no differences were detected between groups (p = 0.37). Reduction of the bone defect depth was significant for OFD (0.70 mm; p = 0.005) but not for EMD (0.04 mm; p = 0.86), while no differences were detected between them (p = 0.87). Both EMD (0.69 degrees; p = 0.82) and OFD (5.71 degrees; p = 0.24) showed an improvement in defect angle measurements but no significant differences were observed after 24 months or between the groups (p = 0.35). Conclusion: Linear radiographic analysis was not able to demonstrate superiority of EMD treated infrabony defects when compared to ODF after 24 months. (AU)

• Processo FAPESP: 00/12285-0 - Estudo clinico comparativo, em humanos, da reparação de defeitos infra-ósseos de 2 ou 3 paredes tratados com membrana absorvível ou proteína da matriz do esmalte
• Beneficiário: Luiz Antonio Pugliesi Alves de Lima
• Modalidade de apoio: Auxílio à Pesquisa - Regular