AIa307Thr and Asn680Ser Polymorphisms of FSHR Gene in Human Reproduction Outcomes

Autor(es)

Trevisan, Camila Martins ^[1] ; Peluso, Carla ^[1] ; Cordts, Emerson Barchi ^[1] ; de Oliveira, Renato ^[1] ; Christofolini, Denise Maria ^[1] ; Barbosa, Caio Parente ^[1] ; Bianco, Bianca ^[1]

Afiliação do(s) autor(es)

^[1] ABC, Fac Med, Human Reprod & Genet Ctr, BR-09060650 Santo Andre, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CELLULAR PHYSIOLOGY AND BIOCHEMISTRY; v. 34, n. 5, p. 1527-1535, 2014.
• Citações Web of Science: 10

Resumo

Background/Aims: It is known that some markers of ovarian stimulation can help to personalize the treatment, adjusting the dose of exogenous rFSH, thus preventing excessive wear of the patient. We aimed to evaluate Ala307Thr and Asn680Ser genotypes of the FSHR gene in infertile women and correlate the findings with the results of ovarian response and assisted reproduction outcomes. Methods: Cross-sectional study covering 149 infertile women submitted to assisted reproduction treatment. Genotyping of FSHR variants were performed using TaqMan methodology by real time PCR. FSH and estradiol were measured by ELFA. The data was analyzed statistically. Results: The frequencies of the FSHR Ala307Thr and Asn680Ser genotypes considering the ovarian hyper stimulation response also did not differ statistically. Considering assisted reproduction outcomes, we observed that the polymorphism Ala307Thr have a statistical difference for the number of MII oocytes and embryos (p=0,051 and p=0.037, respectively), which the genotype Ala/Ala showed more embryos. The polymorphisms did not determine the FSH and estradiol serum levels and the ovarian response in the assisted reproduction treatment. Conclusions: The polymorphisms Ala307Thr and Asn680Ser did not determine the FSH and estradiol serum levels and the ovarian response in the assisted reproduction treatment. However, we observed that the Ala307Thr may influence the number of embryos produced. Copyright (C) 2014 S. Karger AG, Basel (AU)

• Processo FAPESP: 11/15045-4 - Avaliação de polimorfismos dos genes Amh e AMHR2 em mulheres inférteis e sua correlação com resultados de reprodução assistida
• Beneficiário: Carla Peluso de Paiva
• Linha de fomento: Bolsas no Brasil - Mestrado
• Processo FAPESP: 11/08681-1 - Avaliação de polimorfismos do gene FSHr, Amh e AMHR2 em mulheres inférteis e sua correlação com resultados de reprodução assistida
• Beneficiário: Bianca Alves Vieira Bianco
• Linha de fomento: Auxílio à Pesquisa - Regular