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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

AIa307Thr and Asn680Ser Polymorphisms of FSHR Gene in Human Reproduction Outcomes

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Author(s):
Trevisan, Camila Martins [1] ; Peluso, Carla [1] ; Cordts, Emerson Barchi [1] ; de Oliveira, Renato [1] ; Christofolini, Denise Maria [1] ; Barbosa, Caio Parente [1] ; Bianco, Bianca [1]
Total Authors: 7
Affiliation:
[1] ABC, Fac Med, Human Reprod & Genet Ctr, BR-09060650 Santo Andre, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: CELLULAR PHYSIOLOGY AND BIOCHEMISTRY; v. 34, n. 5, p. 1527-1535, 2014.
Web of Science Citations: 10
Abstract

Background/Aims: It is known that some markers of ovarian stimulation can help to personalize the treatment, adjusting the dose of exogenous rFSH, thus preventing excessive wear of the patient. We aimed to evaluate Ala307Thr and Asn680Ser genotypes of the FSHR gene in infertile women and correlate the findings with the results of ovarian response and assisted reproduction outcomes. Methods: Cross-sectional study covering 149 infertile women submitted to assisted reproduction treatment. Genotyping of FSHR variants were performed using TaqMan methodology by real time PCR. FSH and estradiol were measured by ELFA. The data was analyzed statistically. Results: The frequencies of the FSHR Ala307Thr and Asn680Ser genotypes considering the ovarian hyper stimulation response also did not differ statistically. Considering assisted reproduction outcomes, we observed that the polymorphism Ala307Thr have a statistical difference for the number of MII oocytes and embryos (p=0,051 and p=0.037, respectively), which the genotype Ala/Ala showed more embryos. The polymorphisms did not determine the FSH and estradiol serum levels and the ovarian response in the assisted reproduction treatment. Conclusions: The polymorphisms Ala307Thr and Asn680Ser did not determine the FSH and estradiol serum levels and the ovarian response in the assisted reproduction treatment. However, we observed that the Ala307Thr may influence the number of embryos produced. Copyright (C) 2014 S. Karger AG, Basel (AU)

FAPESP's process: 11/08681-1 - Evaluation of FSHr, Amh and AMHR2 gene polymorphisms in infertile women and its correlation with human reproduction outcomes
Grantee:Bianca Alves Vieira Bianco
Support type: Regular Research Grants
FAPESP's process: 11/15045-4 - Evaluation of Amh and AMHR2 gene polymorphisms in infertile women and its correlation with of assisted reproduction outcomes
Grantee:Carla Peluso de Paiva
Support type: Scholarships in Brazil - Master