Subsets of Memory CD4(+) T Cell and Bactericidal Antibody Response to Neisseria meningitidis Serogroup C after Immunization of HIV-Infected Children and Adolescents

Autor(es)

Milagres, Lucimar G. ^[1] ; Costa, Priscilla R. ^[2] ; Silva, Giselle P. ^[1] ; Carvalho, Karina I. ^[2] ; Pereira-Manfro, Wania F. ^[1] ; Ferreira, Bianca ^[3] ; Barreto, Daniella M. ^[3] ; Frota, Ana Cristina C. ^[3] ; Hofer, Cristina B. ^{[4, 3]} ; Kallas, Esper G. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Estado Rio De Janeiro, Dept Microbiol Immunol & Parasitol, Rio De Janeiro, RJ - Brazil

^[2] Univ Sao Paulo, Sch Med, Div Clin Immunol & Allergy, Sao Paulo - Brazil

^[3] Univ Fed Rio de Janeiro, Sch Med, Dept Prevent Med, Rio De Janeiro, RJ - Brazil

^[4] Univ Fed Rio de Janeiro, Inst Puericultura & Pediat Martagao Gesteira, Rio De Janeiro, RJ - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PLoS One; v. 9, n. 12 DEC 22 2014.
• Citações Web of Science: 1

Resumo

Meningococcal disease is endemic in Brazil, with periodic outbreaks and case fatality rates reach as high as 18 to 20% of cases. Conjugate vaccines against meningococci are immunogenic in healthy children. However, we have previously shown a poor bactericidal antibody response to a Men C conjugate vaccine in Brazilian HIV-infected children and adolescents after a single vaccine administration. The goal of the present work was to investigate associations between bactericidal antibody response induced by MenC vaccine and the frequency and activation profile (expression of CD38, HLA-DR and CCR5 molecules) of total CD4(+) memory T cell sub-populations in HIV-1-infected children and adolescents. Responders to vaccination against MenC had a predominance (about 44%) of CD4(+) T-INTERMEDIATE subset followed by T-TRANSITIONAL memory subset (23 to 26%). Importantly, CD4(+) T-INT frequency was positively associated with bactericidal antibody response induced by vaccination. The positive correlation persisted despite the observation that the frequency T-INT CD38(+)HLA-DR+ was higher in responders. In contrast, CD4(+) T-CENTRAL MEMORY (T-CM) subset negatively correlated with bactericidal antibodies. In conclusion, these data indicate that less differentiated CD+ T cells, like TCM may be constantly differentiating into intermediate and later differentiated CD4(+) T cell subsets. These include CD4 T-INT subset which showed a positive association with bactericidal antibodies. (AU)

• Processo FAPESP: 09/54055-5 - Imunidade mediada por celulas em criancas infectadas pelo virus da imunodeficiencia humana
• Beneficiário: Esper Georges Kallás
• Modalidade de apoio: Auxílio à Pesquisa - Regular