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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Effect of IGF1, GH, and PIT1 markers on the genetic parameters of growth and reproduction traits in Canchim cattle

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Autor(es):
Grossi, Daniela do Amaral [1] ; Buzanskas, Marcos Eli [2] ; Grupioni, Natalia Vinhal [2] ; Paro de Paz, Claudia Cristina [3, 4] ; de Almeida Regitano, Luciana Correia [5] ; de Alencar, Mauricio Mello [5] ; Schenkel, Flavio Schramm [1] ; Munari, Danisio Prado [2]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Guelph, Dept Anim & Poultry Sci, Ctr Genet Improvement Livestock, Guelph, ON N1G 2W1 - Canada
[2] UNESP Univ Estadual Paulista, Dept Ciencias Exatas, Fac Ciencias Agr & Vet, BR-14884900 Jaboticabal, SP - Brazil
[3] Ctr APTA Bovinos Corte, Inst Zootecnia, BR-14174000 Sertaozinho, SP - Brazil
[4] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Genet, BR-14049900 Ribeirao Preto, SP - Brazil
[5] EMBRAPA Pecuaria Sudeste, Empresa Brasileira Pesquisa Agr, BR-13560970 Sao Carlos, SP - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: MOLECULAR BIOLOGY REPORTS; v. 42, n. 1, p. 245-251, JAN 2015.
Citações Web of Science: 9
Resumo

The availability of dense genomic information has increased genome-wide association studies for the bovine species; however research to assess the effect of single genes on production traits is still important to elucidate the genes functions. On this study the association of IGF1, GH, and PIT1 markers with growth and reproductive traits (birth weight, weaning weight, weight at 12 and 18 months of age, preweaning average daily weight gain, age and weight at first calving, and scrotal circumference at 12 and 18 months of age) were assessed by means of the variance component approach. The phenotypes were adjusted and then analyzed under two animal models, one which considered the polygenic and genotype (IGF1, GH or PIT1 markers) effects (Model 1), and the other which considers only the polygenic effect (Model 2). When the likelihood ratio test and the Bonferroni correction was applied at 5 % significance level, the genetic markers for the IGF1, GH, and PIT1 genes did not influence significantly the traits (p > 0.002). However, evidence of association of IGF1 with birth weight (p = 0.06) and GH with weight at first calving (p = 0.03) and with weight at 12 months of age (p = 0.08) was observed. In conclusion we could not confirm the associations between IGF1, GH, and PIT1 and growth traits that were previously reported in Canchim cattle, and no association was observed between these genes and reproductive traits. Future studies involving functional markers of IGF1, GH and PIT1 genes may help to clarify the role of these genes in growth and reproductive processes. (AU)

Processo FAPESP: 08/09393-7 - Associação dos genes do fator do crescimento semelhante à insulina tipo 1, do hormônio do crescimento e do fator de transcrição da pituitária com valores genéticos de idade e peso corporal ao primeiro parto de fêmeas Canchim
Beneficiário:Natalia Vinhal Grupioni
Linha de fomento: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 06/60043-1 - Efeito de marcadores moleculares sobre as caracteristicas de crescimento e reprodutivas de bovinos da raca canchim.
Beneficiário:Daniela Do Amaral Grossi
Linha de fomento: Bolsas no Brasil - Doutorado