Dependence of optical attenuation coefficient and mechanical tension of irradiated human cartilage measured by optical coherence tomography

Autor(es)

Martinho Junior, A. C. ^[1] ; Freitas, A. Z. ^[1] ; Raele, M. P. ^[1] ; Santin, S. P. ^[1] ; Soares, F. A. N. ^[1] ; Herson, M. R. ^[2] ; Mathor, M. B. ^[1]

Afiliação do(s) autor(es)

^[1] CNEN SP, IPEN, Sao Paulo - Brazil

^[2] Monash Univ, Alfred Skin Cell Culture Lab, Melbourne, Vic 3004 - Australia

• Tipo de documento: Artigo Científico
• Fonte: CELL AND TISSUE BANKING; v. 16, n. 1, p. 47-53, MAR 2015.
• Citações Web of Science: 2

Resumo

As banked human tissues are not widely available, the development of new non-destructive and contactless techniques to evaluate the quality of allografts before distribution for transplantation is very important. Also, tissues will be processed accordingly to standard procedures and to minimize disease transmission most tissue banks will include a decontamination or sterilization step such as ionizing radiation. In this work, we present a new method to evaluate the internal structure of frozen or glycerol-processed human cartilages, submitted to various dosis of irradiation, using the total optical attenuation coefficient retrieved from optical coherence tomography (OCT) images. Our results show a close relationship between tensile properties and the total optical attenuation coefficient of cartilages. Therefore, OCT associated with the total optical attenuation coefficient open a new window to evaluate quantitatively biological changes in processed tissues. (AU)

• Processo FAPESP: 08/10437-9 - Estudo dos efeitos da radiação ionizante em cartilagem costal humana por Termogravimetria e Tomografia por Coerência Óptica
• Beneficiário: Monica Beatriz Mathor
• Modalidade de apoio: Auxílio à Pesquisa - Regular