Interlocked Systems in Nanomedicine

Autor(es)

Ornelas-Megiatto, Catia ^[1] ; Becher, Tiago B. ^[1] ; Megiatto, Jr., Jackson D. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, UNICAMP, Inst Chem, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: CURRENT TOPICS IN MEDICINAL CHEMISTRY; v. 15, n. 13, p. 1236-1256, 2015.
• Citações Web of Science: 6

Resumo

The concept of Nanomedicine emerged along with the new millennium, and it is expected to provide solutions to some of modern medicine's unsolved problems. Nanomedicine offers new hopes in several critical areas such as cancer treatment, viral and bacterial infections, medical imaging, tissue regeneration, and theranostics. To explore all these applications, a wide variety of nanomaterials have been developed which include liposomes, dendrimers, nanohydrogels and polymeric, metallic and inorganic nanoparticles. Recently, interlocked systems, namely rotaxanes and catenanes, have been incorporated into some of these chemical platforms in an attempt to improve their performance. This review focus on the nanomedicine applications of nanomaterials containing interlocked structures. The introduction gives an overview on the significance of interdisciplinary science in the progress of the nanomedicine field, and it explains the evolution of interlocked molecules until their application in nanomedicine. The following sections are organized by the type of interlocked structure, and it comprises details of the in vitro and/or in vivo experiments involving each material: rotaxanes as imaging agents, rotaxanes as cytotoxic agents, rotaxanes as peptide transporters, mechanized silica nanoparticles as stimuli responsive drug delivery systems, and polyrotaxanes as drug and gene delivery systems. (AU)

• Processo FAPESP: 13/11519-7 - Síntese de novos nanomateriais baseados em nanohidrogéis supramoleculares biodegradáveis, para aplicações em vectorização de fármacos
• Beneficiário: Cátia Cristina Capêlo Ornelas Megiatto
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/22160-0 - Desenvolvimento de estratégias sintéticas originais para preparar polímeros supramoleculares entrelaçados
• Beneficiário: Jackson Dirceu Megiatto Junior
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores