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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Antifungal Compounds from Cyanobacteria

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Autor(es):
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Shishido, Tania K. [1] ; Humisto, Anu [1] ; Jokela, Jouni [1] ; Liu, Liwei [1] ; Wahlsten, Matti [1] ; Tamrakar, Anisha [1] ; Fewer, David P. [1] ; Permi, Perttu [2] ; Andreote, Ana P. D. [3] ; Fiore, Marli F. [3] ; Sivonen, Kaarina [1]
Número total de Autores: 11
Afiliação do(s) autor(es):
[1] Univ Helsinki, Dept Food & Environm Sci, Viikki Bioctr 1, FI-00014 Helsinki - Finland
[2] Univ Helsinki, Inst Biotechnol, Program Struct Biol & Biophys, Nucl Magnet Resonance Lab, FI-00014 Helsinki - Finland
[3] Univ Sao Paulo, Ctr Nucl Energy Agr, BR-13400970 Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: MARINE DRUGS; v. 13, n. 4, p. 2124-2140, 2015.
Citações Web of Science: 22
Resumo

Cyanobacteria are photosynthetic prokaryotes found in a range of environments. They are infamous for the production of toxins, as well as bioactive compounds, which exhibit anticancer, antimicrobial and protease inhibition activities. Cyanobacteria produce a broad range of antifungals belonging to structural classes, such as peptides, polyketides and alkaloids. Here, we tested cyanobacteria from a wide variety of environments for antifungal activity. The potent antifungal macrolide scytophycin was detected in Anabaena sp. HAN21/1, Anabaena cf. cylindrica PH133, Nostoc sp. HAN11/1 and Scytonema sp. HAN3/2. To our knowledge, this is the first description of Anabaena strains that produce scytophycins. We detected antifungal glycolipopeptide hassallidin production in Anabaena spp. BIR JV1 and HAN7/1 and in Nostoc spp. 6sf Calc and CENA 219. These strains were isolated from brackish and freshwater samples collected in Brazil, the Czech Republic and Finland. In addition, three cyanobacterial strains, Fischerella sp. CENA 298, Scytonema hofmanni PCC 7110 and Nostoc sp. N107.3, produced unidentified antifungal compounds that warrant further characterization. Interestingly, all of the strains shown to produce antifungal compounds in this study belong to Nostocales or Stigonematales cyanobacterial orders. (AU)

Processo FAPESP: 13/09192-0 - Salinas do Pantanal da Nhecolândia (MS): Hidro-bio-geoquímica de uma área úmida singular
Beneficiário:Laurent BARBIERO
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 09/13455-0 - Cianobactérias no bioma caatinga: isolamento, morfologia, filogenia e bioprospecção
Beneficiário:Tânia Keiko Shishido
Linha de fomento: Bolsas no Brasil - Doutorado