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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Soft Matter Assemblies as Nanomedicine Platforms for Cancer Chemotherapy: A Journey from Market Products Towards Novel Approaches

Autor(es):
Jaeger, Eliezer [1] ; Giacomelli, Fernando C. [2]
Número total de Autores: 2
Afiliação do(s) autor(es):
[1] Acad Sci Czech Republic, Inst Macromol Chem, Prague - Czech Republic
[2] Univ Fed ABC, Ctr Ciencias Nat & Humanas, Santo Andre - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo de Revisão
Fonte: CURRENT TOPICS IN MEDICINAL CHEMISTRY; v. 15, n. 4, p. 328-344, 2015.
Citações Web of Science: 7
Resumo

The current review aims to outline the likely medical applications of nanotechnology and the potential of the emerging field of nanomedicine. Nanomedicine can be defined as the investigation area encompassing the design of diagnostics and therapeutics at the nanoscale, including nanobots, nanobiosensors, nanoparticles and other nanodevices, for the remediation, prevention and diagnosis of a variety of illnesses. The ultimate goal of nanomedicine is to improve patient quality-of-life. Because nanomedicine includes the rational design of an enormous number of nanotechnology-based products focused on miscellaneous diseases, a variety of nanomaterials can be employed. Therefore, this review will focus on recent advances in the manufacture of soft matterbased nanomedicines specifically designed to improve diagnostics and cancer chemotherapy efficacy. It will be particularly highlighted liposomes, polymer-drug conjugates, drug-loaded block copolymer micelles and biodegradable polymeric nanoparticles, emphasizing the current investigations and potential novel approaches towards overcoming the remaining challenges in the field as well as formulations that are in clinical trials and marketed products. (AU)

Processo FAPESP: 12/14087-8 - Desenvolvimento de sistemas poliméricos nanoestruturados com tamanho controlado e sua interação com ambientes biológicos
Beneficiário:Fernando Carlos Giacomelli
Linha de fomento: Auxílio à Pesquisa - Regular