| Texto completo | |
| Autor(es): |
Previato, M.
[1]
;
Borim, M. P.
[1]
;
Liberatore, Jr., R. D. R.
[2, 3]
;
Pires, A. C.
[2, 4]
;
Dias, M. A. F.
[2, 4]
;
Brandao de Mattos, C. C.
[1]
;
de Mattos, L. C.
[1]
Número total de Autores: 7
|
| Afiliação do(s) autor(es): | [1] FAMERP, Fac Med Sao Jose do Rio Preto, Dept Mol Biol, Immunogenet Lab, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil
[2] FAMERP, Fac Med Sao Jose do Rio Preto, Dept Med 2, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil
[3] HB FUNFARME, Fac Reg Med, Hosp Base, Pediat Endocrinol Outpatient Clin, Sao Jose do Rio Preto - Brazil
[4] HB FUNFARME, Fundacao Fac Reg Med, Hosp Base, Endocrinol Outpatient Clin, Sao Jose Do Rio Preto - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Vox Sanguinis; v. 108, n. 3, p. 281-286, APR 2015. |
| Citações Web of Science: | 2 |
| Resumo | |
Background and ObjectivesThe red blood cell Le(a-b-) phenotype was proposed as risk factor for type 1 diabetes, but contradictory results were published elsewhere. This study re-examined the potential association between Lewis histo-blood group system and type 1 diabetes. Material and MethodsPatients and controls of both sexes, Caucasians and non-Caucasians, matched by sex, geographical origin and ethnicity were evaluated. The red blood cell Lewis phenotypes were identified by gel column agglutination and also inferred from the FUT2 and FUT3 genotyping. ResultsThe Le(a-b-) phenotype was prevalent in patients with type 1 diabetes, and the Le(a-b+) phenotype was prevalent in controls when both were determined by gel columns agglutination. No differences were observed in the frequencies of the Le(a-b-) phenotype inferred from the FUT2 and FUT3 genotyping between patients and controls. ConclusionsThe Lewis red blood cell phenotyping and genotyping reveal divergence in the association of Le(a-b-) phenotype and type 1 diabetes. (AU) | |
| Processo FAPESP: | 09/17540-2 - Sistemas histo-sanguíneos como fatores de risco para a toxoplasmose ocular |
| Beneficiário: | Luiz Carlos de Mattos |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 13/10050-5 - Avaliação sorológica, molecular e de imagens em pacientes com lesão ativa e ou reagudização de infecção ocular por Toxoplasma gondii: um estudo de follow-up |
| Beneficiário: | Mariana Previato |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |