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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Impact of OSA on Cardiovascular Events After Coronary Artery Bypass Surgery

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Autor(es):
Uchoa, Carlos Henrique G. [1, 2] ; Danzi-Soares, Naury de Jesus [1] ; Nunes, Flavia S. [1] ; de Souza, Altay A. L. [3] ; Nerbass, Flavia B. [1] ; Pedrosa, Rodrigo P. [4] ; Cesar, Luiz Antonio M. [5] ; Lorenzi-Filho, Geraldo [1] ; Drager, Luciano F. [2, 6, 7]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Med, Div Pulm, Sleep Lab, BR-05403900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Med, Hypertens Unit, BR-05403900 Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Physicobiol Dept, Sao Paulo - Brazil
[4] Univ Pernambuco, Sleep & Heart Lab, Pronto Socorro Cardiol Pernambuco PROCAPE, Pernambuco - Brazil
[5] Univ Sao Paulo, Sch Med, Clin Unit Chron Coronary Heart Dis, BR-05403900 Sao Paulo - Brazil
[6] Univ Sao Paulo, Sch Med, Inst Heart InCor, BR-05403900 Sao Paulo - Brazil
[7] Univ Sao Paulo, Sch Med, Hypertens Unit, Div Renal, BR-05403900 Sao Paulo - Brazil
Número total de Afiliações: 7
Tipo de documento: Artigo Científico
Fonte: CHEST; v. 147, n. 5, p. 1352-1360, MAY 2015.
Citações Web of Science: 37
Resumo

BACKGROUND: The impact of OSA on new cardiovascular events in patients undergoing coronary artery bypass graft (CABG) surgery is poorly explored. METHODS: Consecutive patients referred for CABG underwent clinical evaluation and standard polysomnography in the preoperative period. CABG surgery data, including percentage of off-pump and on-pump CABG, number of grafts, and intraoperative complications, were collected. The primary end point was major adverse cardiac or cerebrovascular events (MACCEs) (combined events of all-cause death, myocardial infarction, repeated revascularization, and cerebrovascular events). Secondary end points included individual MACCEs, typical angina, and arrhythmias. Patients were evaluated at 30 days (short-term) and up to 6.1 years (long term) aft er CABG. RESULTS: We studied 67 patients (50 men; mean age, 58 +/- 8 years; mean BMI, 28.5 +/- 4.1 kg/m(2)). OSA (apnea-hypopnea index >= 15 events/h) was present in 56% of the population. The patients were followed for a mean of 4.5 years (range, 3.2-6.1 years). No differences were observed in the short-term follow-up. In contrast, MACCE (35% vs 16%, P = .02), new revascularization (19% vs 0%, P = .01), episodes of typical angina (30% vs 7%, P = .02), and atrial fibrillation (22% vs 0%, P = .0068) were more common in patients with than without OSA in the long-term follow-up. OSA was an independent factor associated with the occurrence of MACCE, repeated revascularization, typical angina, and atrial fibrillation in the multivariate analysis. CONCLUSIONS: OSA is independently associated with a higher rate of long-term cardiovascular events aft er CABG and may have prognostic and economic significance in CABG surgery. (AU)

Processo FAPESP: 12/02953-2 - Impacto da apneia obstrutiva do sono e da duração do sono sobre a progressão das doenças cardiovasculares
Beneficiário:Luciano Ferreira Drager
Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores