Ethanol modulates the synthesis and catabolism of retinoic acid in the rat prostate

Autor(es)

Fioruci-Fontanelli, Beatriz Aparecida ^{[1, 2]} ; Chuffaa, Luiz Gustavo A. ^[1] ; Mendes, Leonardo O. ^{[1, 2]} ; Pinheiro, Patricia Fernanda F. ^[1] ; Justulin, Jr., Luis Antonio ^[3] ; Felisbino, Sergio Luis ^[3] ; Martinez, Francisco Eduardo ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista, Inst Biosci, Dept Anat, BR-18618970 Botucatu, SP - Brazil

^[2] Univ Estadual Campinas, Struct & Cell Biol Program, Campinas, SP - Brazil

^[3] Univ Estadual Paulista, Inst Biosci, Dept Morphol, BR-18618970 Botucatu, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: REPRODUCTIVE TOXICOLOGY; v. 53, p. 1-9, JUN 2015.
• Citações Web of Science: 1

Resumo

All-trans retinoic acid (atRA) maintains physiological stability of the prostate, and we reported that ethanol intake increases atRA in the rat prostate; however the mechanisms underlying these changes are unknown. We evaluated the impact of a low- and high-dose ethanol intake (UChA and UChB strains) on atRA metabolism in the dorsal and lateral prostate. Aldehyde dehydrogenase (ALDH) subtype 1A3 was increased in the dorsal prostate of UChA animals while ALDH1A1 and ALDH1A2 decreased in the lateral prostate. In UChB animals, ALDH1A1, ALDH1A2, and ALDH1A3 increased in the dorsal prostate, and ALDH1A3 decreased in the lateral prostate. atRA levels increased with the low activity of CYP2E1 and decreased with high CYP26 activity in the UChB dorsal prostate. Conversely, atRA was found to decrease when the activity of total CYP was increased in the UChA lateral prostate. Ethanol modulates the synthesis and catabolism of atRA in the prostate in a concentration-dependent manner. (C) 2015 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 11/03394-4 - Metabolismo do ácido retinóico nos lobos dorsais e laterais da próstata de ratos consumidores crônicos de etanol (UCH)
• Beneficiário: Beatriz Aparecida Fioruci Fontanelli
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 11/13713-0 - Efeito do consumo crônico de etanol sobre o metabolismo do ácido retinóico no lobo dorsal e lateral da próstata de ratos UCH
• Beneficiário: Francisco Eduardo Martinez
• Modalidade de apoio: Auxílio à Pesquisa - Regular