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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Maternally acquired IgG immunity in neonates born to renal transplanted women

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Autor(es):
Viana, Patricia Oliveira [1] ; Ono, Erika [1] ; Saraiva Dinelli, Maria Isabel [1] ; Costa-Carvalho, Beatriz Tavares [1] ; Nunes dos Santos, Amelia Miyashiro [1] ; Sass, Nelson [2] ; de Moraes-Pinto, Maria Isabel [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Dept Pediat, Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo, Dept Obstet, Sao Paulo, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Vaccine; v. 33, n. 27, p. 3104-3109, JUN 17 2015.
Citações Web of Science: 4
Resumo

Neonates born to renal transplanted women are exposed in utero to immunosuppressors and to antenatal conditions that may predispose the neonate to a high risk of prematurity and intrauterine growth retardation. These factors might interfere with the transfer of maternal IgG immunity. Total IgG levels and specific antibodies to measles, varicella, tetanus, Haemophilus influenzae type b (Hib) and Streptococcus pneumoniae (serotypes 4,6B,9V,14,18C,19F and 23F) were evaluated on maternal and cord blood samples of 23 sets of renal transplanted women and their newborns and 32 sets of healthy women-newborns at term. Total IgG levels were measured by nephelometry and specific antibodies, by ELISA. Renal transplanted mothers had lower median tetanus antibodies (0.67 IU/mL) than controls (1.53 IU/mL; p = 0.017). Neonates from renal transplanted mothers had lower median tetanus antibodies (0.95 IU/mL) than controls (1.97 IU/mL, p = 0.008). Antibodies to measles, varicella, Hib and the 7 serotypes of S. pneumoniae were similar between groups. Maternal antibodies were associated with an increase in neonatal antibodies for all antigens; gestational age was associated with an increase in Hib neonatal antibodies. Preeclampsia was associated with a decrease in neonatal total IgG and serotype 4 S. pneumoniae antibodies; chronic hypertension was associated with a decrease in neonatal serotype 6B S. pneumoniae antibodies. As neonates from transplanted women may be born with lower tetanus antibodies than controls, efforts should be made to keep maternal vaccines up-to-date. Clinical antenatal care with control of preeclampsia, chronic hypertension and prevention of premature delivery might also contribute to neonatal antibody levels to specific antigens at birth. (C) 2015 Elsevier Ltd. All rights reserved. (AU)

Processo FAPESP: 08/11670-9 - Crianças nascidas de mulheres submetidas a transplante renal: avaliação imunológica, passagem transplacentária de anticorpos e resposta a vacinação
Beneficiário:Maria Isabel de Moraes Pinto
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 09/01179-9 - Transporte transplacentário de anticorpos em crianças nascidas de mulheres submetidas a transplante renal.
Beneficiário:Patrícia Oliveira Viana
Linha de fomento: Bolsas no Brasil - Doutorado