| Texto completo | |
| Autor(es): |
Ribeiro, F. V.
[1]
;
Santos, V. R.
;
Bastos, M. F.
;
de Miranda, T. S.
;
Vieira, A. R.
[2, 3, 4, 5, 6]
;
de Figueiredo, L. C.
;
Duarte, P. M.
[7]
Número total de Autores: 7
|
| Afiliação do(s) autor(es): | [1] Univ Paulista, Dent Res Div, Sch Dent, Sao Paulo - Brazil
[2] Univ Pittsburgh, Sch Dent Med, Dept Oral Biol, Pittsburgh, PA - USA
[3] Univ Pittsburgh, Sch Dent Med, Dept Pediat Dent, Pittsburgh, PA - USA
[4] Univ Pittsburgh, Sch Dent Med, Ctr Craniofacial & Dent Genet, Pittsburgh, PA - USA
[5] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Human Genet, Pittsburgh, PA 15261 - USA
[6] Univ Pittsburgh, Clin & Translat Sci Inst, Pittsburgh, PA - USA
[7] Univ Guarulhos, Ctr Posgrad & Pesquisa, Dent Res Div, Dept Periodontol, BR-07023070 Centro, SP - Brazil
Número total de Afiliações: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ORAL DISEASES; v. 18, n. 2, p. 147-152, MAR 2012. |
| Citações Web of Science: | 7 |
| Resumo | |
OBJECTIVE: The Family with sequence similarity 5 member C (FAM5C) has been suggested to contribute in aggressive periodontitis. However, there is no data regarding its role in chronic periodontitis. The aim of this study was to evaluate the FAM5C expression in chronic periodontitis and to study association of FAM5C with key immunoinflammatory markers. MATERIAL AND METHODS: Gingival biopsies were harvested from periodontally healthy subjects (n = 10) and chronic periodontitis subjects (n = 15). The levels of mRNA of FAM5C, interleukin (IL)-17, IL-6, IL-23, IL-10, IL-4, interferon-c, toll-like receptor (TLR)-2, TLR-4, osteoprotegerin (OPG), receptor activator of NF-kappa B ligand (RANKL), tumor necrosis factor (TNF)-alpha, transforming growth factor-beta, transcription factor forkhead box p3, and transcription factor orphan nuclear receptor C2 were evaluated by real-time polymerase chain reaction. RESULTS: FAM5C mRNA levels were not different between periodontally healthy and diseased tissues (P > 0.05). Gene expressions of IL-17, TNF-alpha, OPG, RANKL, TLR-2, and TLR-4 were higher in periodontitis, when compared to periodontally healthy sites (P < 0.05), while no differences between groups were observed for the other genes evaluated (P > 0.05). There were no correlations between the gene expression of FAM5C and the other immunoinflammatory markers (P > 0.05). CONCLUSION: Within the limits of this study, it seems that FAM5C expression does not contribute to chronic periodontitis. Oral Diseases (2012) 18, 147-152 (AU) | |
| Processo FAPESP: | 08/04280-0 - Expressão gênica em sítios com periodontite crônica em indivíduos portadores de Diabetes Mellitus |
| Beneficiário: | Poliana Mendes Duarte |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |