Polymorphous low-grade adenocarcinoma of the upper lip: 11 cases of an uncommon diagnosis

Autor(es)

Fonseca, Felipe Paiva ^[1] ; Brierley, Daniel ^[2] ; Wright, John M. ^[3] ; Santos-Silva, Alan Roger ^[1] ; Almeida, Oslei Paes ^[1] ; Rocha, Andre Caroli ^[4] ; Van Heerden, Willie F. ^{[3, 5]} ; Hunter, Keith D. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Piracicaba Dent Sch, Oral Diag Dept Pathol & Semiol, Campinas, SP - Brazil

^[2] Univ Sheffield, Sch Clin Dent, Acad Unit Oral & Maxillofacial Pathol, Sheffield S10 2TN, S Yorkshire - England

^[3] Texas A&M Univ, Baylor Coll Dent, Dept Diagnost Sci, Dallas, TX - USA

^[4] Univ Sao Paulo, Sch Med, Clin Hosp, Oral & Maxillofacial Surg & Traumatol Serv, BR-05508 Sao Paulo - Brazil

^[5] Univ Pretoria, Fac Hlth Sci, Sch Dent, Dept Oral Pathol & Oral Biol, ZA-0002 Pretoria - South Africa

• Tipo de documento: Artigo Científico
• Fonte: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY; v. 119, n. 5, p. 566-571, MAY 2015.
• Citações Web of Science: 2

Resumo

Objective. The aim of this case study was to describe an international case series of polymorphous low-grade adenocarcinoma (PLGA) affecting the upper lip. Material and Methods. Over a 30-year-period, the files of five pathology services were reviewed for PLGA affecting the upper lip. Hematoxylin and eosin-stained slides were reviewed by three oral and maxillofacial pathologists, and microscopic features were described. Clinical data were retrieved from patients' medical records. Results. The review identified 11 cases of upper lip PLGAs, with a complete set of clinical data available for 5 cases. There was a male predominance (1.2:1), and the mean age was 58.7 years. Most cases presented as small asymptomatic swellings that resembled benign tumors. All patients underwent surgery, and no recurrences or metastases were reported in the 8 cases from which follow-up data were available. Microscopically, the typical polymorphic architectural arrangement of PLGA was seen in all cases, with lobular, trabecular, papillary, and cribriform patterns identified. Perineural invasion, normal gland entrapment, Indian filing, and concentric growth were frequently identified. Conclusion. PLGA must be included in the list of differential diagnoses of tumors affecting the upper lip because of its similar clinical presentation to benign entities. The follow-up data available from 8 of 11 cases suggest that these tumors follow a low-grade clinical course, similar to the majority of palatal cases of PLGA. (AU)

• Processo FAPESP: 12/07519-9 - Semaphorinas e neuropilinas em tumores de glândulas salivares
• Beneficiário: Felipe Paiva Fonseca
• Modalidade de apoio: Bolsas no Brasil - Doutorado