Longitudinal effect of curcumin-photodynamic antimicrobial chemotherapy in adolescents during fixed orthodontic treatment: a single-blind randomized clinical trial study

Autor(es)

Paschoal, Marco Aurelio ^[1] ; Zanin Moura, Cintia Maria ^[2] ; Jeremias, Fabiano ^[3] ; Souza, Juliana Feltrin ^[4] ; Bagnato, Vanderlei S. ^[5] ; Giusti, Jucaira S. M. ^[5] ; Santos-Pinto, Lourdes ^[3]

Afiliação do(s) autor(es)

^[1] CEUMA Univ, Master Program Dent, BR-65075120 Sao Luis, MA - Brazil

^[2] Univ Estadual Paulista, Araraquara Dent Sch, UNESP, BR-14801903 Araraquara, SP - Brazil

^[3] Univ Estadual Paulista, Araraquara Dent Sch, Dept Pediat Dent, UNESP, BR-14801903 Araraquara, SP - Brazil

^[4] Positivo Univ UP, Sch Dent, Masters Program Clin Dent, BR-81280330 Curitiba, Parana - Brazil

^[5] Univ Sao Paulo, Sao Carlos Inst Phys, Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Lasers in Medical Science; v. 30, n. 8, p. 2059-2065, NOV 2015.
• Citações Web of Science: 7

Resumo

White spot lesions are one of the concerns during the fixed orthodontic treatment. Thus, the aim of the present study was to evaluate the antimicrobial/anti-inflammatory effect of curcumin-photodynamic antimicrobial chemotherapy (c-PACT) and chlorhexidine varnish on the plaque accumulation and gingival bleeding in adolescents under fixed orthodontic treatment. A randomized clinical trial was performed with an initial number of 45 patients being distributed into three groups: group I-chlorhexidine varnish 2 %, group II-placebo varnish, and group III-c-PACT (curcumin at 1.5 mg.mL(-1)) exposed to blue Light-emitting diode (LED) light at 450 nm (power density = 165 mW.cm(-2), fluency = 96 J.cm(-2), total dose = 150.7 J). The treatments were performed for four consecutive times with an interval of 1 week each. After the interventions, two calibrated examiners (Kappa value = 0.75) analyzed the dental plaque accumulation by plaque index (PI) and gingivitis condition by gingival bleeding index (GBI) with 1 and 3 months of follow-up after the treatments comprised a final sample of 35 patients. No significant difference was found to PI between the groups during baseline and 1-month period. Group III (1.52 +/- 0.51) presented significance difference from group I (0.91 +/- 0.75) and group II (1.03 +/- 0.51) at 3 months of follow-up. In this same period, there was more plaque accumulation with significant statistical difference (P a parts per thousand currency signaEuro parts per thousand 0.05) in comparison to the other periods to all studied groups. There was a GBI reduction statistically significant to groups I and III at 1-month follow-up in comparison to other periods. No effect was verified to dental plaque accumulation after the photodynamic application mediated with curcumin activated with a blue LED light. (AU)

• Processo FAPESP: 10/12093-5 - Efetividade da terapia fotodinâmica e clorexidina sobre o biolfime e saliva de adolescentes
• Beneficiário: Cintia Maria Zanin de Moura
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica