Interaction of chitosan beads with a copper-naproxen metallodrug

Autor(es)

Martins, Douglas de J. ^[1] ; Hanif-Ur-Rehman ^[1] ; Alves Rico, Samara R. ^[1] ; Costa, Iguatina de M. ^[1] ; Pio Santos, Andrea C. ^[1] ; Szszudlowski, Rachel G. ^[1] ; Silva, Denise de Oliveira ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, BR-05508000 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: RSC ADVANCES; v. 5, n. 109, p. 90184-90192, 2015.
• Citações Web of Science: 3

Resumo

This manuscript reports a novel hybrid system containing a copper-drug entrapped into the chitosan biopolymer. Chitosan beads (CTb) were prepared and investigated for interaction with a copper metallodrug (CuNpx) of the naproxen (HNpx) non-steroidal anti-inflammatory drug. The loading capacity of CTb for CuNpx suggests a sponge-like behavior for copper-drug entrapping at a CuNpx concentration range from 10(-4) to 10(-2) mol L-1. A novel CTb/CuNpx hybrid material formed by the copper-drug loaded into chitosan beads was prepared and characterized by elemental analysis, scanning electron microscopy, electronic absorption spectroscopy, FTIR spectroscopy, X-ray diffractometry and thermal analysis. The CTb/CuNpx hybrid material was coated with Acrycoat S100, and its behavior in gastric/intestinal pH simulated solutions was investigated to verify potential releasing properties. The coated beads showed a capacity to release naproxen in a sustained release manner for at least 24 h. (AU)

• Processo FAPESP: 05/60596-8 - Espécies complexas com potencial aplicação em bioinorgânica, catálise, farmacologia e química ambiental: concepção, preparação, caracterização e reatividade
• Beneficiário: Ana Maria da Costa Ferreira
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 11/06592-1 - Metalofármacos anti-inflamatórios e antitumorais: reatividade, propriedades e interações com matrizes hospedeiras biocompatíveis
• Beneficiário: Denise de Oliveira Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular