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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Theoretical assessment of feasibility to sequence DNA through interlayer electronic tunneling transport at aligned nanopores in bilayer graphene

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Autor(es):
Prasongkit, Jariyanee [1, 2] ; Feliciano, Gustavo T. [3] ; Rocha, Alexandre R. [4] ; He, Yuhui [5] ; Osotchan, Tanakorn [6] ; Ahuja, Rajeev [7, 8] ; Scheicher, Ralph H. [8]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Nakhon Phanom Univ, Div Phys, Fac Sci, Nakhon Phanom 48000 - Thailand
[2] NanotecKKU Ctr Excellence Adv Nanomat Energy Prod, Khon Kaen 40002 - Thailand
[3] Univ Estadual Paulista UNESP, Inst Chem, Dept Phys Chem, Araraquara, SP - Brazil
[4] Univ Estadual Paulista UNESP, Inst Fis Teor, Sao Paulo, SP - Brazil
[5] Huazhong Univ Sci & Technol, Sch Opt & Elect Informat, Wuhan 430074 - Peoples R China
[6] Mahidol Univ, Dept Phys, Fac Sci, Bangkok 10400 - Thailand
[7] Royal Inst Technol, Dept Mat & Engn, Appl Mat Phys, SE-10044 Stockholm - Sweden
[8] Uppsala Univ, Div Mat Theory, Dept Phys & Astron, SE-75120 Uppsala - Sweden
Número total de Afiliações: 8
Tipo de documento: Artigo Científico
Fonte: SCIENTIFIC REPORTS; v. 5, DEC 4 2015.
Citações Web of Science: 23
Resumo

Fast, cost effective, single-shot DNA sequencing could be the prelude of a new era in genetics. As DNA encodes the information for the production of proteins in all known living beings on Earth, determining the nucleobase sequences is the first and necessary step in that direction. Graphene-based nanopore devices hold great promise for next-generation DNA sequencing. In this work, we develop a novel approach for sequencing DNA using bilayer graphene to read the interlayer conductance through the layers in the presence of target nucleobases. Classical molecular dynamics simulations of DNA translocation through the pore were performed to trace the nucleobase trajectories and evaluate the interaction between the nucleobases and the nanopore. This interaction stabilizes the bases in different orientations, resulting in smaller fluctuations of the nucleobases inside the pore. We assessed the performance of a bilayer graphene nanopore setup for the purpose of DNA sequencing by employing density functional theory and non-equilibrium Green's function method to investigate the interlayer conductance of nucleobases coupling simultaneously to the top and bottom graphene layers. The obtained conductance is significantly affected by the presence of DNA in the bilayer graphene nanopore, allowing us to analyze DNA sequences. (AU)

Processo FAPESP: 13/02112-0 - Simulações de transporte eletrônico em grafeno utilizando métodos híbridos QM/MM: aplicações no sequenciamento de DNA e detecção de proteínas
Beneficiário:Alexandre Reily Rocha
Linha de fomento: Auxílio à Pesquisa - Regular