Pulse pressure variation and stroke volume variation under different inhaled concentrations of isoflurane, sevoflurane and desflurane in pigs undergoing hemorrhage

Autor(es)

Oshiro, Alexandre Hideaki ^[1] ; Otsuki, Denise Aya ^{[1, 2]} ; Hamaji, Marcelo Waldir M. ^[2] ; Rosa, Kaleizu T. ^[2] ; Ida, Keila Kazue ^[1] ; Fantoni, Denise T. ^[3] ; Costa Auler, Jr., Jose Otavio ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med, Programa Posgrad Anestesiol, Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Lab Invest Med LIM Anestesiol 08, Fac Med, Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Dept Cirurgia, Fac Med Vet & Zootecnia, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Clinics; v. 70, n. 12, p. 804-809, 2015.
• Citações Web of Science: 4

Resumo

OBJECTIVES: Inhalant anesthesia induces dose-dependent cardiovascular depression, but whether fluid responsiveness is differentially influenced by the inhalant agent and plasma volemia remains unknown. The aim of this study was to compare the effects of isoflurane, sevoflurane and desflurane on pulse pressure variation and stroke volume variation in pigs undergoing hemorrhage. METHODS: Twenty-five pigs were randomly anesthetized with isoflurane, sevoflurane or desflurane. Hemodynamic and echocardiographic data were registered sequentially at minimum alveolar concentrations of 1.00 (M1), 1.25 (M2), and 1.00 (M3). Then, following withdrawal of 30% of the estimated blood volume, these data were registered at a minimum alveolar concentrations of 1.00 (M4) and 1.25 (M5). RESULTS: The minimum alveolar concentration increase from 1.00 to 1.25 (M2) decreased the cardiac index and increased the central venous pressure, but only modest changes in mean arterial pressure, pulse pressure variation and stroke volume variation were observed in all groups from M1 to M2. A significant decrease in mean arterial pressure was only observed with desflurane. Following blood loss (M4), pulse pressure variation, stroke volume variation and central venous pressure increased (p<0.001) and mean arterial pressure decreased in all groups. Under hypovolemia, the cardiac index decreased with the increase of anesthesia depth in a similar manner in all groups. CONCLUSION: The effects of desflurane, sevoflurane and isoflurane on pulse pressure variation and stroke volume variation were not different during normovolemia or hypovolemia. (AU)

• Processo FAPESP: 08/57247-0 - Avaliacao da variacao de pressao de pulso (delta pp) frente a diferentes concentracoes inaladas de isofluorano, desfluorano e isofluorano: modelo experimental em suinos
• Beneficiário: José Otávio Costa Auler Junior
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 08/57248-6 - Avaliação da variação de pressão de pulso (Delta PP) frente a diferentes concentrações inaladas de isofluorano, desfluorano e isofluorano: modelo experimental em suínos
• Beneficiário: Alexandre Hideaki Oshiro
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto