Insulin resistance parameters in users of the injectable contraceptive depot medroxyprogesterone acetate during one year of use

Autor(es)

Cursino, Kleber ^[1] ; Sider, Marina ^[1] ; Pavin, Elizabeth Joao ^[2] ; Silva dos Santos, Priscilla de Nazare ^[1] ; Bahamondes, Luis ^[1] ; Zantut-Wittmann, Denise Engelbrecht ^[2] ; Fernandes, Arlete ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, UNICAMP, Fac Med Sci, Dept Obstet & Gynaecol, Campinas, SP - Brazil

^[2] Univ Estadual Campinas, UNICAMP, Fac Med Sci, Div Endocrinol, Dept Clin Med, Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: EUROPEAN JOURNAL OF CONTRACEPTION AND REPRODUCTIVE HEALTH CARE; v. 21, n. 1, p. 22-29, JAN 2 2016.
• Citações Web of Science: 3

Resumo

Objectives The aim of the study was to assess insulin resistance parameters using successive homeostasis model assessment (HOMA) and clinical evaluations in healthy new users of depot medroxyprogesterone acetate (DMPA). Methods A prospective 12-month study was carried out to compare 31 DMPA users with 25 copper intrauterine device (Cu-IUD; TCu380A) users, matched for age (+/- 1 year) and body mass index (BMI; 1 kg/m(2)). Participants met the following criteria: age 18 to 40 years, BMI < 30 kg/m(2), fasting glucose < 5.5 mmol/l, 2-h glucose after a 75 g oral glucose load < 140 mg/dl. BMI, waist circumference, fasting glucose, fasting insulin and HOMA of insulin resistance (HOMA-IR) were evaluated at baseline and after 6 and 12 months of contraceptive use. Insulin resistance was defined as a HOMA-IR value > 2.7. Results The DMPA group showed significant increases in BMI, waist circumference, fasting insulin and HOMA-IR throughout the observation period in relation to baseline. Significant increases in BMI and waist circumference were observed in the DMPA group at 12 months compared with the Cu-IUD group. Five DMPA users had abnormal HOMA-IR values, three of whom had gained > 5 kg in weight at 12 months. Conclusions HOMA-IR represents a useful tool to indicate changes in carbohydrate metabolism in non-obese DMPA users, especially when accompanied by measurement of clinical parameters such as BMI and waist circumference. (AU)

• Processo FAPESP: 09/53293-0 - Estudo prospectivo de avaliação da resistência insulínica, metabolismo de lípedes e repercussão subclínica de doença cardiovascular em mulheres que iniciam o uso do contraceptivo injetável trimestal de acetato de medroxiprogesterona de depósito em segmento de 2 anos
• Beneficiário: Luis Guillermo Bahamondes
• Modalidade de apoio: Auxílio à Pesquisa - Pesquisa em Políticas Públicas para o SUS