Thermal behavior of the beta-blocker propranolol

Autor(es)

Ambrozini, Beatriz ^[1] ; Cervini, Priscila ^[1] ; Gomes Cavalheiro, Eder Tadeu ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Quim Sao Carlos, Dept Quim & Fis Mol, BR-13560970 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY; v. 123, n. 2, p. 1013-1017, FEB 2016.
• Citações Web of Science: 6

Resumo

The thermal behavior of the beta-blocker anti-hypertensive drug propranolol was investigated using thermoanalytical techniques TG-DTA, DSC and the evolved gas analysis by TG-FTIR, providing information regarding thermal stability, decomposition steps, melting point and heat of fusion of the compound. The results pointed for the decomposition in a single mass loss step, after melting. DSC data revealed that cold crystallization occurred in heat-cool-heat cycles, around 165 A degrees C. TG-FTIR presented 1-naphthol, isopropylamine and HCl as principal decomposition products. A tentative mechanism for the thermal behavior of propranolol is presented. (AU)

• Processo FAPESP: 12/09911-3 - Aplicação de análise térmica ao estudo de fármacos antihipertensivos e antibióticos: beta-bloqueadores e tetraciclinas
• Beneficiário: Éder Tadeu Gomes Cavalheiro
• Modalidade de apoio: Auxílio à Pesquisa - Regular